FABP6


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FABP6

A gene on chromosome 5q23-q35 that encodes the ileal fatty acid-binding protein that stimulates gastric acid and pepsinogen secretion, and which binds bile salts and bilirubins. Isoform 2 is expressed in the lower GI tract and is essential for the survival of colon cancer cells in response to bile acid-induced apoptosis.
References in periodicals archive ?
Other genes including FABP6 (fatty acid binding protein 6), downregulated in the prefrontal cortex in major depression [35]; GRIN1 (glutamate ionotropic receptor NMDA subunit), implicated in stress-related psychiatric disorders [40]; HRH1 (histamine receptor H1), known to be blocked by TCAs [41]; and HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1), associated with female depression [42], were likewise differentially methylated.