Representative photomicrographs (400x) showing H&E staining of intestine (a) and Chiu's score (b) was carried out to evaluate the injury degree; quantitative analysis using ELISA method was taken to assay the concentration of diamine oxidase (DAO) (c), D-lactic acid (DLA) (d), and intestinal-type fatty acid-binding protein (FABP2) (e) in serum.
In addition, Lipoxin A4 binding to ALXR could also reduce damage of diamine oxidase (DAO) products, D-lactic acid (DLA), and intestinal-type fatty acid-binding protein (FABP2) release with other mechanisms.
Our study clearly demonstrates a strong association of the 54Thr allele of the FABP2 Ala54Thr polymorphism with MetS The 54Thr risk allele carriers had elevated BMI, and more likely to be of advanced age and male gender.
Risk allele frequency and genetic associations of FABP2 gene Ala54Thr SNP polymorphism with disease phenotypes like insulin resistance, diabetes, MetS etc.
However, a high proportion of the study population was found to be heterozygous for Ala54Thr FABP2 polymorphism (44.1% controls and 22.4%) in our study population.
Overall, present study confirms 54Thr allele of FABP2 gene being a strong risk marker of MetS which seems to exert its role through anthropometric trait BMI in a Pakistani population.
Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women.
FABP2 Ala54Thr polymorphism and diabetes in Chilean elders.
Polymorphism of the FABP2 gene: a population frequency analysis and an association study with cardiovascular risk markers in Argentina.
The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis.
The polymorphism at codon 54 of the FABP2 gene increases fat absorption in human intestinal explants.
Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity.