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[5] Nonstandard abbreviations: AKI, acute kidney injury; GFR, glomerular filtration rate; AKIN, Acute Kidney Injury Network; IL, interleukin; NGAL, neutrophil gelatinase-associated lipocalin; KIM-1, kidney injury molecule 1; MIOX and Miox, myo-inositol oxygenase; cRNA, complementary RNA; GST, glutathione S-transferase; rMIOX, recombinant MIOX; BLAST, basic local alignment search text; H&E, hematoxylin and eosin; FABP1, liver type fatty acid-binding protein 1.
Among this set, Fabp1 (fatty acid-binding protein), also known as a heme-binding protein (Epstein et al.
Expression of FABP1 was much greater in liver, while FABP3 and FABP4 transcripts were much more abundant in mammary tissues.
It has been observed that human liver-and heart-type FABP (FABP1 and FABP3) are expressed in the proximal and distal renal tubular cells, respectively (14, 15), and increased amounts of FABP1 in urine have been postulated as a clinical marker of renal tubulointerstitial damage (16, 17).
The antibodies in human FABP4 ELISA are highly specific for human FABP4, with no detectable cross-reactivity to human FABP1, FABP2, FABP3, or FABP5.