F2RL2

F2RL2

A gene on chromosome 5q13 that encodes a member of the protease-activated receptors (PARs), which belong to the G protein-coupled cell surface receptor family. F2RL2 is a co-factor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4, and plays an essential role in hemostasis and thrombosis.
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Genes APE ESE KJ Expected sum ACOT7 -1.586 -1.516 -1.723 -3.102 APOBEC3F -1.444 -1.558 -1.647 -3.002 APOBEC3G -1.619 -1.376 -1.705 -2.995 ASS1 -1.630 -1.366 -1.834 -2.996 CXCL12 1.564 -7.500 7.597 0.064 F2RL2 2.211 1.454 2.594 3.665 GBP1 -1.729 -1.464 -1.636 -3.193 GLDN 1.569 1.464 1.772 3.033 H1ST1H2AC -1.765 -1.424 -1.558 -3.189 KRT18 -1.796 -1.591 -2.166 -3.387 LYPD1 -1.699 -1.464 -1.591 -3.163 NAMPT 1.860 -7.647 2.757 0.213 PSMB8 -1.597 -1.495 -1.439 -3.092 RCAN1 -1.647 -1.376 -1.444 -3.023 RNY4 2.092 1.361 1.510 3.453 SLC6A1 1.449 1.905 1.586 3.354 SLC02B1 2.990 1.449 3.238 4.439 SRXN1 2.063 1.361 1.952 3.424
We noted up-regulation of genes related to coagulation [tissue factor (F3) and coagulation factor II receptor-like 2 (F2RL2)] and differential regulation of genes related to F3 signaling (FOS, JUN, and NFKBIA).
62192; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unigene), coagulation factor II receptor-like 2 (F2RL2; Unigene accession no.
TaqMan Universal PCR master mix and Taqman Gene Expression pre-developed assays (reagents concentrated and preoptimized mixes of primers and FAM-labeled TaqMan probes) for tissue factor (F3), coagulation factor II receptor-like 2 (F2RL2), coagulation factor VIII associated (F8A1, Unigene accession no.
HPAEC were treated for 4 hr (0, 1, 10, and 100 [micro]g/mL UFP) for F3 Q-PCR analysis or 2 and 24 hr (0, 25, and 100 [micro]g/mL water-soluble and -insoluble UFP fractions) for all F3, F2RL2, F8A1, and HMOX1.
These alterations included up-regulation of tissue factor (F3) (2.7-fold) and coagulation factor II receptor-like 2 (F2RL2) (1.5-fold) and down-regulation of coagulation factor VIII-associated (intronic transcript) 1 (F8A1) (0.8-fold).
The water-soluble fraction tended to increase the expression of F2RL2 (Figure 2B).
Among these were genes related to the coagulation-inflammation circuitry, including up-regulation of F3, F2RL2, IL-6, and IL-8 and downregulation of F8A1.