F2RL1A gene on chromosome 5q13 that encodes a widely expressed G protein-coupled receptor for trypsin and trypsin-like enzymes. F2RL1 helps recruit leukocytes to the sites of inflammation, and is the major protease-activated receptor (PAR) capable of modulating eosinophil function (e.g., proinflammatory cytokine secretion, superoxide production and degranulation). During inflammation, it promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. It is involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of gram-positive and killing of gram-negative bacteria. F2RL1 acts synergistically with IFN-gamma to enhance antiviral responses. It appears to play a role in inflammatory disorders of the joints, lungs, brain, GI tract, periodontium, skin and vascular systems, and in autoimmune disorders
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