KDM2A(redirected from F-box and leucine-rich repeat protein 11)
KDM2AA gene on chromosome 11q13.2 that encodes lysine-specific demethylase 2A of the F-box protein family, which constitute one of the four subunits of the ubiquitin protein ligase complex called SCF (SKP1-cullin-F)-box (which is involved in phosphorylation-dependent ubiquitination). KDM2A may recognise and bind phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs, which are encoded by clusters of satellite repeats at the centromere. It is needed to sustain centromeric integrity and genomic stability, especially during mitosis.
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