FBXW4(redirected from F-box/WD repeat protein 4)
FBXW4A gene on chromosome 10q24 that encodes a member of the F-box/WD-40 gene family, which recruit specific target proteins by WD-40 protein-protein-binding domains for phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. A knockout mouse model of FBXW4 results in absent central digits, underdeveloped/absent metacarpal/metatarsal bones and syndactyly, which is similar to a human counterpart; split hand/foot malformation with an autosomal recessive form characterised by complex rearrangements and duplications map to 10q24.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.