When dosed appropriately, second-generation antipsychotics are preferred over first-generation antipsychotics in this population because they are less likely to cause extrapyramidal symptoms
and other neurologic adverse effects.
In schizophrenia trials, it showed low propensity to induce extrapyramidal symptoms
Commonly Observed Adverse Reactions: The most common adverse reactions (incidence [greater than or equal to] 5% and at least twice the rate of placebo) in patients treated with LATUDA were somnolence, akathisia, extrapyramidal symptoms
, and nausea.
15] The presence and degree of EPSs was assessed by making use of the Extrapyramidal Symptom
Rating Scale (ESRS).
Commonly Observed Adverse Reactions: The most common adverse reactions (incidence > 5% and at least twice the rate of placebo) in patients treated with LATU DA were somnolence, akathisia, extrapyramidal symptoms
, and nausea.
The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms
a PET study.
This pilot investigation follows the drug safety communication from the Food and Drug Administration in February 2011 in which health care providers were notified that the pregnancy section of the medication label for the entire antipsychotic drug class was being changed to reflect the potential risks for extrapyramidal symptoms
(EPS) or withdrawal symptoms noted in newborns whose mothers had been treated with these drugs during the third trimester of pregnancy.
Along with the update to the licenced indications, the Summary of Product Characteristics for quetiapine prolonged release has been updated with respect to several individual safety topics such as: suicidality, weight gain, hyperglycaemia, extrapyramidal symptoms
, akathisia, somnolence, orthostatic hypotension, and dizziness.
Non-specific scales for depression are often not advisable in evaluating depression in schizophrenia populations because of the overlap of negative and extrapyramidal symptoms
of schizophrenia and depressive symptoms (4,5).
It can be associated with extrapyramidal symptoms
, which tend to be self-limited and have rarely been reported in the context of morning sickness.
There is an increased risk of extrapyramidal symptoms
, increases in prolactin (although rare, this can cause breast secretion and enlargement), and metabolic side effects.
haloperidol) have proved effective in adult and paediatric populations, their use has been limited by safety concerns, such as extrapyramidal symptoms