Extragonadal

Extragonadal

In a location other than the reproductive organs.
Mentioned in: Choriocarcinoma
References in periodicals archive ?
Eight-month-old baby girl Ainul Mardhiah who successfully underwent surgery here last week to remove extragonadal germ cell tumour, a rare type of cancer, covering her mouth yesterday had a surprise visitor, Prime Minister Tun Dr Mahathir Mohamad.
Extragonadal teratoma in a domestic turkey (Meleagris gallopavo domestica).
First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors.
The tumor is frequently a component of mixed germ cell tumors, found in the ovary, extragonadal sites along the midline, and, rarely, the fallopian tube as a result of transformation of the migrating germ cells.
To the Editor: Extragonadal, nongestational choriocarcinomas are very rare neoplasms that mostly arise spontaneously in midline structures, such as the retroperitoneum, mediastinum, and vicinity of the pineal body, but they also have been reported in other visceral organs, such as the stomach, esophagus, small bowel, prostate, and urinary bladder.[1] In the last seven decades, there have been only 29 cases of male primary pulmonary choriocarcinoma (PPC) reported in the literature.
Seminomas and nonseminomas are derived from both gonadal and extragonadal anatomic sites and have distinct biological and metastatic properties.
Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis.
[1] The most common sites for extragonadal germ cell tumors (GCTs) are the anterior mediastinum, the retroperitoneum, and the pineal and suprasellar regions.
The extragonadal thymic germinoma was noted in the middle mediastinum of a 23-year-old female without any ovarian pathology and normal levels of serum AFP, B-hCG.
MSKCC investigators reported outcomes with the TICE regimen within a prospective phase I/II trial of 107 patients with relapsed/refractory GCT and unfavorable features for achieving a durable remission to CDCT including an extragonadal primary site, incomplete response to initial therapy or relapse/incomplete response to salvage CDCT [8].
Characteristic Cases N % Diagnosis Brain tumor 62 20.0 Non-Hodgkin lymphoma 43 13.9 Osteosarcoma 42 13.6 Wilms tumor 35 11.3 Ewing's sarcoma 24 7.7 Soft tissue sarcoma 24 7.7 Gonadal germinal tumor 21 6.8 Retinoblastoma 16 5.2 Hepatoblastoma 16 5.2 Hodgkin lymphoma 14 4.5 Neuroblastoma 12 3.9 Extragonadal germinal tumor 1 0.3 TOTAL 310 100.0 Table 3: Effect of maternal age in childhood solid cancers development.
A failure in cell migration to the genital crest can lead to an extragonadal presentation [1].

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