extracellular matrix

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extracellular matrix

the aggregate of proteins secreted by cells.

extracellular matrix

a substance containing collagen, elastin, proteoglycans, glycosaminoglycans, and fluid, produced by cells and in which the cells are embedded. The matrix secreted by chondroblasts, for example, is responsible for the properties of cartilage.

extracellular matrix

Non-living material secreted by cells that fills spaces between the cells in a tissue, protecting them and helping to hold them together. The extracellular matrix may be semifluid or rigidly solid and hard as in bone. It is composed mainly of protein and includes collagens, elastin, reticulin, glycoproteins, proteoglycans, fibronectin, laminins and osteopontin.

extracellular matrix (ECM)


extracellular matrix (eksˈ·tr·selˑ·y·ler māˑ·triks),

n substance produced by cells and secreted into the environment in which the cells are embedded; contains collagen, proteoglycans, glycosaminoglycans, and fluid; can influence the behavior of the cells. Also called
ECM. See also connective tissue.


situated or occurring outside a cell or cells.

extracellular constituents
all of the constituents of the body outside the cells; include water, electrolytes, protein, glucose, enzymes, hormones.
extracellular fluid
all of the body fluid lying outside the cells. Includes intravascular fluid or plasma and the interstitial fluid. That part of the extracellular fluid that is in special cavities which have special characteristics, e.g. synovial fluid, urine, aqueous humor of eye, are called transcellular fluids.
extracellular matrix
the network of proteins and carbohydrates that surround a cell or fill the intercellular spaces.
extracellular space
References in periodicals archive ?
sup][14],[15] MMPs could proteolytically degrade extracellular matrix proteins leading to tumor metastasis, [sup][16] and this process is proteolytically inhibited by TIMPs.
Extracellular matrix protein by standers or active participants in the allograft rejection cascade?
Vitronectin a glioma-derived extracellular matrix protein protects tumor cells from apoptotic death.
But in some women's breasts, collagen, elastin and other extracellular matrix proteins form thick ropes of connective tissue that appear as stringy white material on a mammogram.
The NanoInk platform can control the shape and number of bound cells by varying the underlying pattern geometry and total patterned area of deposited extracellular matrix proteins.
Expression of extracellular matrix proteins in human dental pulp stem cells depends on the donor tooth conditions.
9) Immunoprofiling of the epithelial lining and the capsule using cytokeratins and extracellular matrix proteins revealed that the OOC was a well formed and more organized cyst as compared to OKC.
The topics include analyzing dynamic gene express in a microfluidic living cell array, mechano-transduction and the study of cellular forces, image-based cell sorting using microscale electrical and optical actuation, pharmacokinetic-pharmacodynamic models on a chip, controlling the cellular microenvironment, and subtractive methods for forming microfluidic gels of extracellular matrix proteins.
In health, these cells are thought to play a role in extracellular matrix turnover via their ability to synthesize extracellular matrix proteins as well as matrix-degrading enzymes (matrix metallo-proteinases [MMPs]).
Integrins are protein receptors that bind to extracellular matrix proteins, and a2b1 and a5b1 are two integrins that mediate mammary epithelial cell adhesion and migration on collagen and fibronectin, respectively.
His experimental research concerns the role of extracellular matrix proteins in nervous system development, function, and disease.

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