Materials and Methods Fungal Species Trichoderma harzianum JF419706, as a biocontrol agent, and the soil-borne fungal pathogens (Alternaria alternata, Exserohilum rostratum
, Fusarium oxysporum, Pythium ultimum, Macrophomina phaseolina and Rhizoctonia solani) were obtained during our previous work (Alamri et al.
For example, the 2002 outbreak of fungal meningitis was caused by injected steroids contaminated with Exophiala dermatitidis, and the 2012-2015 outbreak of fungal meningitis and other infections resulted from methylprednisolone contaminated by Exserohilum rostratum
A black mold, Exserohilum rostratum
, was found in 151 cases and 23 additional species of fungi were identified from patients.
coli, Clostridium difficile infections, multi-drug resistant tuberculosis, Acinetobacter infections, infections due to NDM-1 (New Delhi metallo-beta-lactamase) producers, the Exserohilum rostratum
incident, mucormycosis, Lyme borreliosis, Plasmodium knowlesi, measles, pertussis, and Buruli ulcer.
Mold can even infect the central nervous system, often fatally, as occurred in a 2012 outbreak of meningitis from epidural injections contaminated by Exserohilum rostratum
Although the index patient (1) had a laboratory-confirmed Aspergillus fumigatus infection, the fungus most often identified, including in unopened vials of methylprednisolone acetate (MPA), remains Exserohilum rostratum
, a common black mold found on plants and in soil (2).
Sealed vials of the steroid, made by the New England Compounding Center in Massachusetts, contained exserohilum rostratum
, a fungus found in soil and plants.
Early tests had shown fungus in unopened vials of the medication, but it took until Thursday to confirm it was the type which causes the rare form of meningitis: Exserohilum rostratum
The CDC has confirmed that the fungus exserohilum rostratum
was present in at least 10 people stricken with the infection.
Effect of carbon sources on the production of extracellular cell wall degrading enzymes by Exserohilum rostratum
The Mycotic Diseases Branch Laboratory at CDC confirmed the presence of Exserohilum rostratum
, an environmental mold and the primary pathogen in this outbreak, in lots 08 and 06 (3); detection of E.