exotoxin

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Related to Exotoxins: Endotoxins

exotoxin

 [ek´so-tok″sin]
a potent toxin formed and excreted by the bacterial cell and found free in the surrounding medium; exotoxins are the most poisonous substances known. They are protein in nature and heat labile, and are detoxified with retention of antigenicity by treatment with formaldehyde. Bacteria of the genus Clostridium are the most frequent producers of exotoxins; diphtheria, botulism, and tetanus are all caused by such toxins. adj., adj ex´otoxic.

ex·o·tox·in

(ek'sō-tok'sin),
A specific, soluble, antigenic, usually heat labile, injurious substance elaborated by certain gram-positive or gram-negative bacteria; it is formed within the cell, but is released into the environment where it is rapidly active in extremely small amounts; most exotoxins are proteinaceous (MW 70,000-900,000) and can have the toxic portion of the molecule destroyed by heat, prolonged storage, or chemicals; the nontoxic but antigenic form is a toxoid.

exotoxin

(ĕk′sō-tŏk′sĭn)
n.
A poisonous substance secreted by a microorganism and released into the medium in which it grows.

ex·o·tox·in

(eks'ō-tok'sin)
A specific, soluble, antigenic, usually heat labile, injurious substance elaborated by some bacterial species; it is formed within the cell but is released into the environment where it is rapidly active in extremely small amounts; most exotoxins are proteinaceous in nature.
Synonym(s): extracellular toxin.

exotoxin

A powerful protein poison, formed by some bacteria, which is released and which may cause severe damage either locally or, if carried away by the blood, at a remote distance. Diphtheria exotoxin destroys throat lining tissue, where the organism settles, but can also travel to damage the heart and the kidneys.

exotoxin

a poison produced by a living CELL and released into the environment. It can affect various ORGANS and systems of the body.

Exotoxin

A poisonous secretion produced by bacilli which is carried in the bloodstream to other parts of the body.
Mentioned in: Diphtheria

ex·o·tox·in

(eks'ō-tok'sin)
A specific, soluble, antigenic, usually heat labile, injurious substance elaborated by certain gram-positive or gram-negative bacteria.
References in periodicals archive ?
Mutational analysis of superantigen activity responsible for the induction of skin erythema by streptococcal pyrogenic exotoxin C.
GAS secretes several pyrogenic exotoxins including SpeA, SpeB, SpeC, and SpeD.
Among these, the genes associated with lipopolysac-charides (LPS), cell wall, multi-drug efflux pumps, protease, exotoxin A, hemolysin, type II secretion system, attachment, motility, chemotaxis and biofilm formations, are more interesting [12, 13].
It causes dramatic infections and intoxications as protein exotoxins either singly or in combination are the major virulence factors that determine the clinical manifestion, morbidity and mortatity [38].
aureus are determined by several exotoxins. Staphylococcal superantigens (SSAg) are one such family of exotoxins produced by S.
Once the GAS has penetrated the epithelial barrier, the actions of bacterial exotoxins damage the host cell and provoke immune responses.
Klenner, M.D., "Its neutralizing action on certain toxins, exotoxins, virus infections, endotoxins and histamine is in direct proportion to the amount of the lethal factor involved and the amount of ascorbate given.
The resulting HA is characterized by low amounts of nucleic acids, proteins, bacterial endotoxins, exotoxins and microbial contamination which reduces hypersensitivity reactions when the material is injected either as linear or crosslinked HA.
More strikingly, the exotoxins produced by many pathogenic bacteria are encoded in the genome of lysogenic phages.
perfringens can produce at least 20 exotoxins, with alpha-toxin being the most virulent, causing cell destruction by hydrolysis of key cell membrane components and lysis of erythrocytes, leukocytes, platelets, fibroplasts and muscle cells.
First, Aeromonas species can produce highly toxic exotoxins, which may lead to extensive myonecrosis as well as necrotizing fasciitis.