exosome

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exosome

(ĕk′sō-sōm′)
n.
1. A tiny vesicle created and released from the plasma membrane of various types of cells, especially immune cells, and capable of inducing antigen-specific immune responses.
2. A cellular protein complex containing enzymes that degrade nuclear and cytoplasmic RNA.

exosome

(ĕks′ō-sōm″) [″ + Gr. soma, body]
An intracellular complex that degrades and processes messenger RNA molecules.

exosome

a protein complex containing NUCLEASES involved in degrading mRNA in eukaryotes.
References in periodicals archive ?
Exosomes which have been described as "ttiny bubbles, released from cells and packaged with molecular mail" travel the bloodstream shuttling proteins and genetic informationn between cells.
Creative Biolabs has made an outstanding contribution to exosome purification services and created proven protocols to purify exosomes from plasma and other body fluids with decreased co-purification of non-exocrine proteins.
Exosomes are potential biomarkers for cancer progression and neurodegenerative disease but it can be difficult to identify what tissue a specific exosome comes from.
"Our prior studies have shown that the fetal exosomes signal to the mother's body that her/his organs have fully matured, which triggers the labor and delivery process," lead researcher Ramkumar Menon, an associate professor in the department of obstetrics and gynecology at University of Texas Medical Branch, (https://www.utmb.edu/newsroom/article12213.aspx) said in a statement.
ArunA Bio is harnessing the natural abilities of neural exosomes to cross the blood brain barrier and enhance the body's anti-inflammatory, self-repair and protective mechanisms to treat a range of neurodegenerative disorders.
In conjunction, the company's newly granted European patent, which has been assigned the No 2419144, provides coverage for loading of exogenous genetic material into exosomes as well as targeted exosome-mediated delivery to tissues and organs of interest.
"Little wonder, then, that regenerative medicine researchers are increasingly turning to exosomes: packets of beneficial biomolecules released by stem cells."
The exosomes are important in lean, healthy individuals in maintaining homeostasis, but when fat gets 'sick' - the most common reason for this is too much weight gain - it can change its phenotype, becoming inflammatory, and disrupts how our organs function, from how our skeletal muscle and liver metabolize sugar to how our blood vessels process cholesterol.
The company also presented research based on its purified amniotic fluid exosome technology it is developing.
Exosomes are obtained from bone marrow-derived mesenchymal stem cells (MSCs) and purified using a proprietary filtration process.
"It has been shown that exosomes can be developed as carriers for delivering drugs," Alahari said in a statement.