exonucleases


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exonucleases

Enzymes that break down DNA and RNA molecules, starting at the ends of the molecular chains. Exonucleases split off nucleotides one at a time from the end of a chain and may be specific for either end.
References in periodicals archive ?
Lemon, "Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication," Proceedings of the National Academy of Sciences of the United States of America, vol.
Screening of human cancers for FEN-1 mutations revealed that defects could be identified that affect 5' exonuclease activity and GEN activity.
For example, in viruses and bacteria, Fen1 homologs include T4 RNaseH, T5 5'-3' exonuclease, and the proofreading element of bacterial Polymerase 1.
Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair.
Accordingly, enzymes called exonucleases pick up where UDGases and other base cutters leave off, excising damaged nucleotides.
Remaining bound to the DNA molecule until complete removal of the phosphorylated strand is another advantage of this enzyme in comparison to other exonucleases (32).
Lambda exonuclease was purchased from Thermofisher SCIENTIFIC (Canada).
However, if the DNA polymerase used has an associated 5'-3' exonuclease activity (e.g., the enzyme isolated from Thermus aquaticus, T.