TGF-[alpha] is a 50 amino acid mitogenic polypeptide that has been detected from a variety of exocrine glands
of body including lacrimal glands, pancreas and in the striated ducts of both human submandibular and sublingual salivary glands (Yasui et al., 1992; Mogi et al., 1995; Humprey-Beher et al., 1994; Chiang et al., 2001; Ogbureke et al., 1995; Dernyk, 1988).
Sjogren's syndrome is a chronic autoimmune disease characterized by mononuclear cell infiltration and progressive injury in exocrine glands
. Typical findings of SjS are mouth and eye dryness.
The presence of these autoantibodies is related to a specific SS diagnosis, in particular in young patients with severe dysfunction in exocrine glands
VAMP8 is one of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, which are required when exocrine glands
release secretory granules .
Sjogren's syndrome is a chronic autoimmune disorder of the exocrine glands
characterized by inflammation and lymphocytic infiltrates of the affected glands .
Sjogren's syndrome (SS) is a common chronic autoimmune disease which affects mainly the exocrine glands
with a typical focal lymphocytic infiltration, potentially leading to xerostomia and xerophthalmia .
Background: Salivary glands are seromucinous exocrine glands
concerned with production and secretion of saliva.
(1983) who detected S-100 in various exocrine glands
in the body.
Sjogren's syndrome develops as a result of accumulation of lymphocytes in exocrine glands
. The most common clinical findings include xerostomia and xeropthalmia which occur as a result of involvement of salivary glands and lacrimal glands.
The salivary glands are tubuloacinar exocrine glands
, whose ducts open into oral cavity.
Digestive enzymes are excreted from exocrine glands
(e.g., salivary gland, pancreas, gallbladder, liver) or cells and glands in the gastrointestinal mucosa.
Lead scientist Dr Takashi Tsuji, from the RIKEN Centre for Developmental Biology, said: "Up until now, artificial skin development has been hampered by the fact that the skin lacked the important organs, such as hair follicles and exocrine glands
, which allow the skin to play its important role in regulation.