After 3 days of acclimatization, the rats were randomly divided into 5 groups: normal, model, Euthyrox
, HYDf, and HYDp groups; all rats except those in the normal control group received intragastric administration of PTU at a dosage of 0.01 g/kg daily for 14 days to induce the goitrous model according to previously reports  and were given different treatments for 28 days, as shown in Table 2.
[sup], Trade name of levothyroxine includes Euthyrox
(Merck KGaA, Darmstadt, Germany) and Letrox (Berlin Chemie, Berlin, Germany), and another substitution in China.
Through transfer of knowledge, we will have the technical capabilities to produce more complex medicines, such as hormone therapies like Merck's Euthyrox
A spokesman for Gulf Pharmacy said all drug shortages had been resolved except for Euthyrox
, a thyroid medication supplied by Merck.
The two products to be produced at Neopharma's facilities are Euthyrox
, a synthetic thyroid hormone and Glucophage, for people suffering from type 2 diabetes.
Initially, two Merck Serono products will be manufactured by Neopharma: Euthyrox
, a hormone therapy requiring a very stringent sterile environment for production and packaging; and Glucophage a standard oral treatment for people suffering from type 2 diabetes that helps control blood sugar levels.
The new facility will focus on the bulk production and packaging of Glucophage, Concor and Euthyrox
, Merck's leading brands for the treatment of diabetes, cardiovascular diseases and thyroid disorders respectively.
Neopharma will manufacture hormone therapy Euthyrox
and diabetes treatment Glucophage for the UAE market.