euthyroid sick syndrome


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eu·thy·roid sick syn·drome

abnormalities in levels of hormones and function tests related to the thyroid gland occurring in patients with severe systemic disease. Thyroid function is actually normal in these patients, and it is uncertain whether treatment of these abnormalities would be beneficial.

euthyroid sick syndrome

Lab medicine A “condition” in Pts who are critically ill with nonthyroid diseases that alter serum levels of thyroid hormones which, in absence of underlying nonthyroid illness, would be correctly interpreted as indicating a disease of the thyroid 'axis' Lab Peripheral ↓/inhibition of 5'-deiodinase, the deiodination enzyme, resulting in ↓ peripheral 5'-monodeiodination of thyroxine–T4, reversed, free, and total T3; TSH, TRH, and usually free thyroxine levels are normal. See Hyperthyroidism, Hypothyroidism.

euthyroid sick syndrome

Any derangement in thyroid hormone blood levels in patients affected by another (usually critical) illness. The altered levels of thyroid hormones are not caused by primary thyroid dysfunction; they return to normal when the underlying illness is successfully treated.
References in periodicals archive ?
Alteration in thyroid function in patients with systemic illness: The "euthyroid sick syndrome".
Euthyroid sick syndrome in children with Hodgkin disease.
Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome." Ann Thorac Surg.
Alterations In thyroid function in patients with systemic illness; the "euthyroid sick syndrome." Endocr Rev.
Euthyroid sick syndrome. In: Becker KL, (Eds).Principles and practice of endocrinology and metabolism.
Kaptein, M.D., added that there is no role for [T.sub.3] in the treatment of the euthyroid sick syndrome, either.
Kaptein, M.D., added that there is no role for T3 in the treatment of the euthyroid sick syndrome, either.
Thyroid hormones play an essential part in human metabolism.1 Thyroid hormones support anabolism, intricate in cardiovascular system function (increase heart contractility and cardiac output), and reduce triiodothyronine/reverse triiodothyronine (T3/rT3) ratio, which frequently relates to normal or low thyroid stimulating hormone (TSH) and thyroxine (T4) levels.2 Euthyroid sick syndrome (ESS) is considered when patients with non-thyroidal illness (NTI) demonstrate abnormal thyroid function.2 Among intensive care unit (ICU) patients, ESS or low-T3 syndrome is more common than true hypothyroidism.3,4 A variety of changes in critically ill patients have been observed, including low T3 levels, followed by low T4 and TSH levels.
Euthyroid sick syndrome was characterized as low FT4, FT3 and TSH levels.
The so-called "euthyroid sick syndrome," characterized by reduced serum T3 and T4 concentrations without increased serum TSH secretion, occurs within hours after major surgery.
(b) The hormonal response in euthyroid sick syndrome represents the part of an adaptive response to illness, so the treatment of these systemic illnesses with thyroxine is not of much help.