ethylenediamine

(redirected from Ethylene diamine)
Also found in: Encyclopedia.

ethylenediamine

 [eth´ĭ-lēn-di″ah-mēn]
a clear liquid with an ammonia like odor and a strong alkaline reaction; complexed with theophylline, it forms aminophylline.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

aminophylline (theophylline, ethylenediamine)

Amnivent (UK), Phyllocontin (UK)

Pharmacologic class: Xanthine

Therapeutic class: Bronchodilator

Pregnancy risk category C

Action

Unclear. Thought to directly relax smooth muscle of bronchial airways and increase pulmonary blood flow by inhibiting phosphodiesterase.

Availability

Injection: 250 mg/10 ml

Oral liquid: 105 mg/5 ml

Tablets: 100 mg, 200 mg

Indications and dosages

Symptomatic relief of bronchospasm in patients with acute symptoms who require rapid theophyllinization

Adults (nonsmokers): 0.7 mg/kg/hour I.V. for first 12 hours. Maintenance dosage is 0.5 mg/kg/hour I.V.

Children ages 9 to 16: 1 mg/kg/hour I.V. for first 12 hours. Maintenance dosage is 0.8 mg/kg/hour I.V.

Children ages 6 months to 9 years: 1.2 mg/kg/hour I.V. for first 12 hours. Maintenance dosage is 1 mg/kg/hour I.V.

Chronic bronchial asthma

Adults and children: Dosage is highly individualized. Common initial dosage is 16 mg/kg/24 hours I.V. or 400 mg/24 hours I.V. in divided doses at 6- or 8hour intervals. If needed, dosage may be increased 25% at 3-day intervals.

Dosage adjustment

• Heart failure

• Hepatic disease

• Elderly patients

• Smokers

Off-label uses

• Dyspnea in patients with chronic obstructive pulmonary disease (COPD)

Contraindications

• Hypersensitivity to xanthine compounds or ethylenediamine

• Seizure disorders

Precautions

Use cautiously in:

• COPD, diabetes mellitus, glaucoma, renal or hepatic disease, heart failure or other cardiac or circulatory impairment, hypertension, hyperthyroidism, peptic ulcer, severe hypoxemia

• active peptic ulcer disease

• elderly patients

• neonates, infants, and young children.

Administration

• For I.V. use, dilute according to label directions and infuse at a rate no faster than 25 mg/minute.

• Don't give in I.V. solutions containing invert sugar, fructose, or fat emulsions.

• Give oral form at meals with 8 oz of water.

Adverse reactions

CNS: irritability, dizziness, nervousness, restlessness, headache, insomnia, stammering speech, abnormal behavior, mutism, unresponsiveness alternating with hyperactivity, seizures

CV: palpitations, sinus tachycardia, extrasystoles, marked hypotension, arrhythmias, circulatory failure

GI: nausea, vomiting, diarrhea, epigastric pain, hematemesis, gastroesophageal reflux, anorexia

GU: urine retention (in men with enlarged prostate), diuresis, increased excretion of renal tubular cells and red blood cells, proteinuria

Metabolic: hyperglycemia

Musculoskeletal: muscle twitching

Respiratory: tachypnea, respiratory arrest

Skin: flushing

Other: fever, hypersensitivity reactions (including exfoliative dermatitis and urticaria)

Interactions

Drug-drug. Adenosine: decreased antiarrhythmic effect of adenosine

Barbiturates, nicotine, phenytoin, rifampin: decreased aminophylline blood level

Beta-adrenergic blockers: antagonism of aminophylline effects

Calcium channel blockers, cimetidine, ciprofloxacin, disulfiram, erythromycin, hormonal contraceptives, influenza vaccine, interferon, methotrexate: elevated aminophylline blood level

Carbamazepine, isoniazid, loop diuretics (such as furosemide): increased or decreased aminophylline blood level

Ephedrine, other sympathomimetics: toxicity, arrhythmias

Lithium: increased lithium excretion

Drug-diagnostic tests. Aspartate aminotransferase, glucose: increased levels

Drug-herbs. Cayenne: increased risk of aminophylline toxicity

Drug-behaviors. Smoking: increased aminophylline elimination

Patient monitoring

Monitor aminophylline blood level. Adjust dosage if patient has signs or symptoms of toxicity (tachycardia, headache, anorexia, nausea, vomiting, diarrhea, restlessness, and irritability).

• Assess for arrhythmias, especially after giving loading dose.

• Check vital signs and fluid intake and output.

• Monitor patient's response to drug, and assess pulmonary function test results.

Patient teaching

• Advise patient to take oral doses at meals with 8 oz of water.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Advise patient to establish effective bedtime routine to minimize insomnia.

• Caution patient not to change aminophylline brands.

• If patient smokes, tell him to notify prescriber if he stops smoking; dosage may need to be adjusted.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

eth·yl·ene·di·a·mine

(eth'il-ēn-dī'ă-mēn),
A volatile colorless liquid of ammoniacal odor and caustic taste; the dihydrochloride is used as a urinary acidifier. Combined with theophylline to make aminophylline, a water-soluble salt suitable for intravenous or rectal administration.
Farlex Partner Medical Dictionary © Farlex 2012

eth·yl·ene·di·a·mine

(eth'il-ēn-dī'ă-mēn)
A volatile colorless liquid of ammoniac odor and caustic taste; the dihydrochloride is used as a urinary acidifier. Combined with theophylline to make aminophylline, a water-soluble salt suitable for intravenous or rectal administration.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

eth·yl·ene·di·a·mine

(eth'il-ēn-dī'ă-mēn)
A volatile colorless liquid of ammoniac odor and caustic taste; the dihydrochloride is used as a urinary acidifier.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Ethylene diamine and tetraethylenepetamine were purchased from Kanto Chemical Co.
To understand complexation in the aqueous phase, the distribution ratio of the [M(en).sub.2] and [M(en).sub.3] [[(en).sub.2] = ethylene diamine and [(en).sub.3] = trimethylene diamine] species in the aqueous phase about each metal ion before extraction, using the formation constant with ethylene di and triamine, was calculated.
This bath contains copper sulfate 5-hydrate, ethylene diamine tetra acetic acid, sodium hydroxide, and formaldehyde 36%.
Synthesis of N, N'- Substituted Pyridinyl Ethylene Diamine Tetraacetic Acid Sodium Salt
The surface of P(AN-co-MMA) nanoparticles was treated with a large excess of an aqueous solution of ethylene diamine where 1g P(AN-co-MMA) nanoparticles was mixed with 20 mL solution of 0.025% EdA, in distilled water, and kept in water bath maintained at 80[degrees]C for 1h.
In simplest terms, patients undergoing chelation therapy are given a chelating agent such as disodium ethylene diamine tetraacetic acid (EDTA), often through intravenous injection.
Its relation to the use of ethylene diamine tetra acetic acid (EDTA) as an anticoagulant has been described in all reports.
Standard chemicals, ethylene diamine (EDA), diethylene glycol diglycidyl ether (DGE), nuclear stain Hoechst 33342, and the peptide Arg-Gly-Asp-Ser (RGD) were obtained from Sigma-Aldrich (Steinheim, Germany).
The company said that the proprietary next generation formula does not contain Ethylene diamine tetracetic acid (EDTA) or any other stabilisation and chelating agents and is free of preservatives.
The materials are Ethylene Diamine Tetra Acetic Acid Tetra and Sodium Salt (EDTANA4 Powder).
The company added the proprietary new formulation, which does not contain Ethylene diamine tetracetic acid or any other stabilization and chelating agents and is free of preservatives, will replace the currently marketed product.