essential thrombocythemia

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thrombocythemia

 [throm″bo-si-the´me-ah]
essential thrombocythemia (hemorrhagic thrombocythemia) a clinical syndrome with repeated spontaneous hemorrhages, either external or into the tissues, and a greatly increased number of circulating platelets, considered one of the myeloproliferative disorders. Called also megakaryocytic leukemia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

essential thrombocythemia

Essential thrombocytosis Hematology A primary myeloproliferative disorder of older–age 55-75–adults, or less commonly of young ♀, with a platelet count is > 600 x 109/L; ET has many clinical features of P vera; it affects the same age group, is accompanied by splenomegaly, has similar BM findings, intensity of leukocytosis Diagnosis Polycythemia Vera Study Group criteria Treatment Hydroxyurea, a myelosuppressant, prevents recurrent thromboses. See Polycythema vera.
Essential thrombocythemia-diagnostic criteria
1. Platelets > 1 x 109 /L (US: < 1000/mm3)
2. Hb < 2.05 mmol/L (US < 13.0 g/dL)
3. Iron in BM or if absent, little ↑ in Hb after 1 month of oral iron therapy
4. Absent marrow fibrosis by biopsy and
5. Absent Philadelphia chromosome
Polycythemia Vera Study Group
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Essential thrombocytosis (ET) has rarely been reported with autoimmune rheumatic disorders.
For example, we know that essential thrombocytosis (ET, MPN) patients can display morphological aberrant thrombocytes in the absence of an absolute elevated thrombocyte count (currently the cut-off point for the diagnosis ET is >450 x 109/L as one of the major criteria).
Primary thrombocytosis (also known as essential thrombocytosis) is an unregulated abnormal production of platelets originating in the bone marrow.
Polycythemia vera (PV), idiopathic myelofibrosis (IMF), and essential thrombocytosis (ET) have been traditionally classified under the "the non CML chronic myeloproliferative neoplasms"2 because they share the features: involvement of a multipotent hematopoietic progenitor cell.6 Dominance of the transformed clone over non-transformed hematopoietic progenitor cells.7-9
Given the presence of cardiovascular risk factors with initially mild angina, essential thrombocytosis with thrombocytosis despite standard treatment, and the lack of a recent coronary angiography, it was justified to rule-out an acute coronary syndrome and clinically significant coronary artery disease, which was done by coronary angiography.
CMML diagnosis was made based on the above findings, persistent peripheral blood monocytosis [greater than or equal to] 1 x [10.sup.9]/L, with monocytes accounting for [greater than or equal to]10% of the WBC count, no evidence of PDGFRA/PDGFRB, <20% blasts in the blood and bone marrow, not meeting WHO criteria for BCR-ABL1 positive chronic myeloid leukemia, primary myelofibrosis, polycythemia vera, or essential thrombocytosis and all other causes of monocytosis excluded [7].
A bone marrow biopsy done six days after admission showed some clusters of atypical megakaryocytes that could be consistent with essential thrombocytosis; thus the patient was started on plateletpheresis and hydroxyurea.
Doi et al., "Heparin-induced thrombocytopenia in essential thrombocytosis," Journal of Stroke and Cerebrovascular Diseases, vol.
His medical history included essential thrombocytosis, hypothyroidism, and a remote episode of shingles.
Characterization of 35 new cases with four different MPL W515 mutations and essential thrombocytosis or primary myelofibrosis.
Samuelsson, "Essential thrombocytosis: a criteria diagnosis.
It is well established that essential thrombocytosis in myeloproliferative diseases is associated with an increased risk of thrombosis due to the presence of giant platelets (1).

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