Mach

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Mach

(mahk),
Ernst, scientist in Hapsburg Empire, 1838-1916. See: Mach band, Mach number.

CASP8

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis, as well as various stages of embryological development. CASP8 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is involved in the programmed cell death induced by Fas and various apoptotic stimuli. It is highly expressed in peripheral blood leukocytes and in the spleen, thymus and liver.

Molecular pathology
CASP8 has been detected in the insoluble fraction of affected brain regions in Huntington disease, suggesting a role in neurodegenerative diseases.
References in periodicals archive ?
Briefly describe one way each of the following individuals influenced the development of the philosophy of science: Auguste Comte, Ernst Mach, Henri Poincare, Albert Einstein.
Ernst Mach's concept arose from two fundamentally different methods of measuring the speed of rotation.
(18) Ernst Mach, "Die Leitfaden meiner naturwissenschaftlichen Erkenntnislehre und ihre Aufnahme durch die Zeitgenossen," Scientia, vol.
But it was soon recognised that his foundation of economic theory closely follows the principles of the so-called Empiriocriticism (or early neo-positivism) of Ernst Mach (see Spann 1910; von Wieser 1911).
Examples of such alternative thinkers are the Frenchman Rene Descartes (1596-1650), the Dutchman Christiaan Huygens (1629-1695), the German Gottfried Leibniz (1646-1716), the Irishman George Berkeley (1685-1753), the East-Prussian Immanuel Kant (1724-1804) and the already mentioned Austrian, Ernst Mach (1838-1916).
Skeptics, led by the physicist/philosopher Ernst Mach, denounced the "atomists" and the statistical magicians for straying into metaphysics.
She stands in worthy succession to Hermann von Helmholtz and Ernst Mach, whose nineteenth-century experiments in sensory perception laid the groundwork for an ethnography of listening.
First, for his portrayal of the character of scientific knowledge, Lenoir draws upon William James' pragmatism, as well as the phenomenology of Ernst Mach and others.
After her discourse on Beller, Barnouw moves to a description of the artistic and intellectual contributions of Adolph Loos, Karl Kraus, Ludwig Wittgenstein, Sigmund Freud, Ernst Mach, and Robert Musil.
The intellectual breadth of this book is admirable and more than compensates for occasional errors of detail (for example, the physicist and philosopher Ernst Mach is misquoted and the novelist Robert Musil, a fierce critic of Mach, is wrongly described as his `disciple').
Their first glimpse of the observatory was from the hopper, as it descended toward the big crater named after the physicist Ernst Mach. Sprawled across the crater floor was the solar system's largest radio telescope.