ERBB3

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ERBB3

A gene on chromosome 12q13 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases which binds and is activated by neuregulins and NTAK.

Molecular pathology
ERBB3 amplification and overexpression has been described in multiple cancers, including prostate, bladder and breast.
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References in periodicals archive ?
The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 2003; 284(l):54-65.
Tran, "Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-a)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation," International Journal of Oncology, vol.
Epidermal growth factor receptor (EGFR), a transmembrane glycoprotein, is classified to the prototype of receptor tyrosine kinases (TKs) family that includes eGfR, ErbB-2, ErbB-3, and ErbB-4.
Andren-Sandberg, "K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB2 and erbB-3 in resected pancreatic ductal adenocarcinoma," Cancer, vol.
Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.
Competitive-differential polymerase chain reaction for gene dosage estimation of erbB-1 (egfr), erbB-2, and erbB-3 oncogenes.
Normal cells and the majority of breast cancers carry 2 copies of the erbB-2 gene on chromosome 17 and express low levels of p185.[80,81] Since this transmembrane receptor has homology to other family members (epidermal growth factor receptor [EGFR], erbB-3, and erbB-4), clinical tests must be specific for erbB-2 (as opposed to cross-reacting with homologous family members) and specific enough to detect amplification (increased gene copy number) or protein overexpression above the normal level.