The deaf and the dumb: the biology of ErbB-2 and ErbB-3
. Exp Cell Res 2003; 284(l):54-65.
Tran, "Inhibition of ErbB-2 and ErbB-3
expression by quercetin prevents transforming growth factor alpha (TGF-a)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation," International Journal of Oncology, vol.
Epidermal growth factor receptor (EGFR), a transmembrane glycoprotein, is classified to the prototype of receptor tyrosine kinases (TKs) family that includes eGfR, ErbB-2, ErbB-3
, and ErbB-4.
Andren-Sandberg, "K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB2 and erbB-3
in resected pancreatic ductal adenocarcinoma," Cancer, vol.
Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3
are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.
Competitive-differential polymerase chain reaction for gene dosage estimation of erbB-1 (egfr), erbB-2, and erbB-3
Normal cells and the majority of breast cancers carry 2 copies of the erbB-2 gene on chromosome 17 and express low levels of p185.[80,81] Since this transmembrane receptor has homology to other family members (epidermal growth factor receptor [EGFR], erbB-3
, and erbB-4), clinical tests must be specific for erbB-2 (as opposed to cross-reacting with homologous family members) and specific enough to detect amplification (increased gene copy number) or protein overexpression above the normal level.