After several rounds of tinkering, the team saw that their RASER system, which stands for "rewiring of aberrant signaling to effector release," was highly specific for cancer cells dependent on ErbB
Of all the dimers formed by members of the ErbB
receptor family, HER-2/FIER-3 heterodimers are the most preferable activators of downstream signaling (10,11).
Expression, Activation, and Inhibition with Lapatinib and Tyrophostin (AG825) in Human Vestibular Schwannomas.
receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: inhibition by gefitinib (ZD1839)," Melanoma Research, vol.
proteins are tyrosine kinase (TK) receptors localized at the plasma membrane level.
The global trial had 483 patients from 19 countries, and showed that afatinib, a once-daily, irreversible ErbB
blocker, significantly delayed tumor growth versus chemotherapy in patients with head and neck squamous cell cancer after failure of previous therapy.
[2.] Graus-Porta D, Beerli RR, Daly JM, Hynes NE (1997) ErbB-2, the preferred heterodimerization partner of all ErbB
receptors, is a mediator of lateral signaling.
Mig-6 can interact directly with all four members of the ErbB
family, including epidermal growth factor receptor (EGFR) and ErbB2-4, to act as a negative feedback regulator of the ErbB
receptor tyrosine kinase pathway [10, 13-15].
gene includes four members: EGFR (ErbB1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4) .
stands for its origin in the Erb-b gene responsible for avian erythroblastosis virus.
Neuregulins and ErbB
receptors in cultured neonatal astrocytes.
Washington, Aug 07 ( ANI ): Tumors develop resistance because a protein called AXL helps cancer cells to circumvent the effects of ErbB
inhibitors, allowing them to grow unchecked, a new study has revealed.