Based on ROC curve, the results for ErbB
2 testing by HPLC in comparison to RT-PCR method were accurate and the area under the curve for both ErbB
2 assay results was 1.
de Bono JS, Rowinsky EK (2002) The ErbB
receptor family: a therapeutic target for cancer.
Neuregulin and erbB
receptor expression in normal and diseased human white matter.
In the new study, Lauffenburger and colleagues set out to identify factors that help tumor cells become resistant to EGFR and other ErbB
The findings underscore the importance of ErbB
signaling in the behavior of intestinal stem cells from which colorectal cancer may arise.
Measuring the protein expression of the erbB
ligand reported to be under the control of ER action, amphiregulin, we found a dose-dependent increase in protein expression.
Neratinib, an irreversible ErbB
receptor tyrosine kinase inhibitor, in patients with advanced ErbB
2-positive breast cancer.
The focus of my thesis, within an understanding of the biology of gliomas, is the role of the erbB
family of proteins.
We know that dysregulation of ErbB
receptors plays a role in the underlying mechanisms of SCC of the lung and the fact that afatinib targets this family of receptors rather than only EGFR, may explain why it offered additional benefits for this patient population.
The most significant predicted pathways included the transforming growth factor-[beta] (TGF-[beta]) signaling, focal adhesion, extracellular matrix (ECM)-receptor interaction, and ERBB
signaling pathways (Fig.
Its ticker symbol ERBB
symbolizes AmericanGreen's belief that cannabis will gain great and greater recognition as an herbal alternative to prescription drugs and that sustainable organic food will keep people healthy.
KTN3379 blocks the activity of ErbB
3, a member of the ErbB
family of receptor tyrosine kinases, when activated by stimulatory growth factor neuregulin or by other receptor tyrosine kinases, including ErbB
2, when neuregulin is absent.