EGFR

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EGFR

EGFR

A gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.

Molecular pathology
EGFR mutations are associated with lung cancer.

EGFR

Abbreviation for epidermal growth factor receptor.

eGFR

estimated glomerular filtration rate.
References in periodicals archive ?
After several rounds of tinkering, the team saw that their RASER system, which stands for "rewiring of aberrant signaling to effector release," was highly specific for cancer cells dependent on ErbB receptor activity.
Of all the dimers formed by members of the ErbB receptor family, HER-2/FIER-3 heterodimers are the most preferable activators of downstream signaling (10,11).
ErbB Expression, Activation, and Inhibition with Lapatinib and Tyrophostin (AG825) in Human Vestibular Schwannomas.
Walz, "ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: inhibition by gefitinib (ZD1839)," Melanoma Research, vol.
ErbB proteins are tyrosine kinase (TK) receptors localized at the plasma membrane level.
The global trial had 483 patients from 19 countries, and showed that afatinib, a once-daily, irreversible ErbB blocker, significantly delayed tumor growth versus chemotherapy in patients with head and neck squamous cell cancer after failure of previous therapy.
[2.] Graus-Porta D, Beerli RR, Daly JM, Hynes NE (1997) ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling.
Mig-6 can interact directly with all four members of the ErbB family, including epidermal growth factor receptor (EGFR) and ErbB2-4, to act as a negative feedback regulator of the ErbB receptor tyrosine kinase pathway [10, 13-15].
The ErbB gene includes four members: EGFR (ErbB1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4) [9].
ErbB stands for its origin in the Erb-b gene responsible for avian erythroblastosis virus.
Washington, Aug 07 ( ANI ): Tumors develop resistance because a protein called AXL helps cancer cells to circumvent the effects of ErbB inhibitors, allowing them to grow unchecked, a new study has revealed.