EGFR

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EGFR

EGFR

A gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.

Molecular pathology
EGFR mutations are associated with lung cancer.

EGFR

Abbreviation for epidermal growth factor receptor.

eGFR

estimated glomerular filtration rate.
References in periodicals archive ?
Based on ROC curve, the results for ErbB land ErbB2 testing by HPLC in comparison to RT-PCR method were accurate and the area under the curve for both ErbB land ErbB2 assay results was 1.
de Bono JS, Rowinsky EK (2002) The ErbB receptor family: a therapeutic target for cancer.
Neuregulin and erbB receptor expression in normal and diseased human white matter.
In the new study, Lauffenburger and colleagues set out to identify factors that help tumor cells become resistant to EGFR and other ErbB inhibitors.
The findings underscore the importance of ErbB signaling in the behavior of intestinal stem cells from which colorectal cancer may arise.
Measuring the protein expression of the erbB ligand reported to be under the control of ER action, amphiregulin, we found a dose-dependent increase in protein expression.
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer.
The focus of my thesis, within an understanding of the biology of gliomas, is the role of the erbB family of proteins.
We know that dysregulation of ErbB receptors plays a role in the underlying mechanisms of SCC of the lung and the fact that afatinib targets this family of receptors rather than only EGFR, may explain why it offered additional benefits for this patient population.
The most significant predicted pathways included the transforming growth factor-[beta] (TGF-[beta]) signaling, focal adhesion, extracellular matrix (ECM)-receptor interaction, and ERBB signaling pathways (Fig.
Its ticker symbol ERBB symbolizes AmericanGreen's belief that cannabis will gain great and greater recognition as an herbal alternative to prescription drugs and that sustainable organic food will keep people healthy.
KTN3379 blocks the activity of ErbB3, a member of the ErbB family of receptor tyrosine kinases, when activated by stimulatory growth factor neuregulin or by other receptor tyrosine kinases, including ErbB2, when neuregulin is absent.