221) Use: pharmaceutical Use: pharmaceutical Class: vasopeptidase Class: thrombin inhibitor inhibitor 10 Bentazone Equilin
[25057-89-0] [474-86-2] (score = 0.
CEE consists of 50% to 70% estrone and 22% to 32% equilin
and 7 or more other poorly characterized estrogens, not found in the human female.
Additionally, in a recent review article by Zhao and Brinton (2006), coadministration of two of three neuroprotective estrogens (17 [beta]-estradiol, equilin
, and [DELTA]89-dehydroestrone) exerted a greater neuroprotective efficacy than individual estrogens in neurodegenerative insults through rat and human studies (Liqin Zhao, 2005) (Class 3).
One of them is equilin
, which is present in horses but not in women.
In Anne Walch's article, "Hormones and Menopause Revisited" Jun/July 04, the paragraph beginning "Premarin, also known as conjugated equilin
estrogen (CEE) .
Premarin contains equilin
, a horse estrogen that can remain in women for about 13 weeks.
Holtorf has replied that "evidence-based medicine does not mean that data should be ignored until a randomized trial of a particular size and duration is completed"--noting that estriol has been used for decades without reported safety concerns and that Premarin[R] contains the non-human estrogen equilin
sulfate, which promotes cancer.
Premarin, also known as conjugated equilin
estrogen (CEE), is derived from pregnant mare's urine.
Unlike bioidentical estrogen creams that provide the hormones found naturally in the human female body, horse estrogen contains equilin and other equine estrogens found exclusively in horses
The human female body contains enzymes to metabolize the natural proportion of estriol, estradiol, and estrone, but not horse estrogens such as equilin.
In addition, metabolism of equilin to equilenin and 17-hydroxyequilenin may contribute to the estrogen stimulatory effect of [conjugated estrogen] therapy.