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a form of human erythropoietin produced by recombinant technology and having the same amino acid sequence and mechanism of action as endogenous erythropoietin. Used in treatment of anemia from various causes, including chronic renal failure, zidovudine therapy, and cancer chemotherapy; also used prior to surgery in anemic patients to reduce the need for blood transfusion. Administered intravenously or subcutaneously. It is available in two forms, designated epoetin alfa (the form used in the United States) and epoetin beta (used in various other countries). Called also recombinant human erythropoietin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
EPOA gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
epoetinHuman erythopoetin made by genetic engineering for use as a drug to treat severe anaemia Brand names are Eprex and Neorecormon.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005