epitope

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determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ep·i·tope

(ep'i-tōp),
The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor.
[epi- + -tope]
Farlex Partner Medical Dictionary © Farlex 2012

epitope

(ĕp′ĭ-tōp′)
n.
A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

epitope

Any site on a biomolecule (antigenic determinant) which can evoke antibody formation. The minimum size of a molecule capable of evoking antibody formation is about 1 kD; if the molecule is smaller, as with haptens, it may evoke an immune response by associating with a carrier protein. Large non-polymeric molecules can have many epitopes. When the van der Waals surfaces of proteins are constructed by X-ray crystallography, epitopic sites appear to require prominently exposed regions—“hills” and “ridges” with surface rigidity. More flexible sites are less antigenic.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

epitope

Immunology Any site on a molecule–an antigenic determinant that can evoke antibody formation. See Idiotype, Immunogenicity.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

ep·i·tope

(ep'i-tōp)
The simplest form of an antigenic determinant, on a complex antigenic molecule, that can combine with antibody or T-cell receptor.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

epitope

An immunologically active discrete site on an ANTIGEN to which an ANTIBODY or a B or T cell receptor actually binds. See also LINEAR EPITOPE and CONFORMATIONAL EPITOPE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

epitope

an antigenic determinant which interacts with an IMMUNOGLOBULIN or T-CELL receptor.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
The combination of the two vaccines provided not only broader epitope coverage, but also a greater therapeutic effect than either vaccine alone.
Screening diagnostic T-cell epitopes against Rv1986, Rv1987, Rv1988, Rv1989c, and Rv1983 in the TB1, NTP1 and HC groups
In this study, we used bioinformatics to predict the secondary and tertiary protein structures and identify the B and T cell epitopes of Der f 33.
Animal-to-animal variation is found in the protective responses evoked by peptide vaccines, including those against FMDV [13, 35], which has been associated with the MHC-restricted recognition of T-cell epitopes included in their composition.
Following the molecular identification of Alternaria spp., B-cell epitopes in the ACTTS gene were predicted.
Staunton, "CD18 activation epitopes induced by leukocyte activation," The Journal of Immunology, vol.
Once received, it will be critical to optimize every new antibody introduced into the laboratory with its preferred epitope retrieval methodology, particularly with respect to pH and buffer, as noted by Shi et al.
Importantly, the results of Semenov and Katrukha suggest that use of valsartan/sacubitril may affect all currently available BNP assays, and may do so in a heterogeneous fashion: those BNP assays based on epitopes found in the more vulnerable regions of BNP (e.g., [Met.sub.4] - [Val.sub.5] or [Arg.sub.17] - [Ile.sub.18]) may report an increase in BNP different from that of assays based on less vulnerable regions.
"Epitope Diagnostics is committed to producing high quality diagnostic kits that may aid in making new discoveries and supporting human health.
He further added that the lack of this knowledge has greatly hampered the development of immune peptide-based therapeutics to control the disease and with the discovery of the disease-causing T cell epitopes, they can now manipulate the activities of the T cells responding to these epitopes to control the disease.