EPCAM

(redirected from Epithelial Cell Adhesion Molecule)
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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
CTCs (EpCAM = epithelial cell adhesion molecule, CK = cytokeratins, DAPI = 4',6-diamidino-2-phenylindole).
The present Competitive Intelligence Report about EpCAM Antagonists provides a competitor evaluation in the field of investigational antibodies and antibody-based constructs targeting epithelial cell adhesion molecule (EpCAM) for treatment of cancer as of April 2009.
According to the FDA-cleared CellSearch system, which has shown clinical relevance, CTCs are defined as epithelial cell adhesion molecule [(EpCAM).
Epithelial cell adhesion molecule and prostate-specific membrane antigen are the most extensively characterized antigens used for immunologic detection of carcinomas (2).