epigenetic landscape


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epigenetic landscape

a concept related to the developmental PATHWAYS along which a cell passes during differentiation. see CANALIZATION.
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Cancer is also an epigenetic disease, because of the presence of genetic alterations in chromatin-remodelling enzymes or their aberrant activations that deregulates the epigenetic landscape. Celine Tiffon concludes that altered pancreatic cancer differentiation may result from epigenetic aberrations because cellular differentiation is also regulated by epigenetic mechanisms.
We also wanted to explore the possibility that the magnitude of the epigenetic changes caused by a typical drug is enough to displace a cell from its normal "groove" in the "epigenetic landscape." This is a term derived from the original work by C.
The potential mechanism for this effect is thought to be due to altered H3K27 methyltransferase and demethylase expression, which leads to changes in the epigenetic landscape of fibroblasts to induce their conversion into cardiomyocyte-like cells.
"The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis."
All of these modifications put together create "the epigenetic landscape," allowing the genome to display unique properties and distribution patterns in different cell types for its cellular identity [10].
The epigenetic landscape theory that he proposed described a process in which gene regulation (e.g., mutations) modulates development.
However, we believe that these approaches collectively share a common basic mechanistic paradigm, that is, modification of the epigenetic landscape. This is supported by the increasing number of studies suggesting epigenetics as the converging mechanism of all IM products and practices.
The concept of oncogene addiction can be mirrored in several descriptions of the aberrant epigenetic landscape found in cancer [100-102].
Their topics include the multifaceted role of YY1 in establishing the cellular epigenetic landscape, identifying mammalian proteins involved in epigenetics, the diverse roles of long non-coding RNA in regulatory processes, the long and short of facioscapulohumeral muscular dystrophy, the environment and the epigenetic transgenerational inheritance of disease, and metabolic inputs into epigenetics.
Regulatory RNAs are known to have roles in controlling the epigenetic landscape of the genome.
The 17 chapters consider relational developmental systems theory and its methodology, its use in positive youth development, and how developmental systems science extends the conceptual and methodological boundaries of developmental science; epigenetic development and evolution, discussing how development directs evolution, and dynamical systems, the epigenetic landscape, and punctuated equilibria; and the connections between neural networks and development, including the nonlinear epigenetic variance in developmental processes and the self-organization metaphor.