Understanding transgenerational epigenetic inheritance
via the gametes
Transgenerational epigenetic inheritance
: Focus on soma to germline information transfer.
However, the epigenetic inheritance
theory should be interpreted with some caution.
Timescales of genetic and epigenetic inheritance
. Cell 128:655668.
The purpose of this article is to explain the basic science of transgenerational epigenetic inheritance
, highlighting particularly intriguing examples from human beings and rodent models, and to suggest that these discoveries require appropriate responses from Christian educators in science and from Christian communities in general.
If the term epigenetic inheritance
is used comprehensively to include mitotic inheritance, then some of the mechanisms underlying phenotypic plasticity may be based on epigenesis.
The case for transgenerational epigenetic inheritance
This structured reference intended for a wide audience of students and researchers introduces epigenetics and epigenetic methods in 16 contributed chapters covering such topics as early life environment, murine models of transgenerational epigenetic inheritance
, centromeres and telomeres, histones (dosage and degradation), DNA methylation changes in cancer, and variant histones H2A and cancer development, among other topics.
Recent years have seen growing interest in the phenomenon of epigenetic inheritance
: the idea that our genome, through epigenetic tags and other structural modifications, transmits more information than the sequence of letters encoded in its DNA base pairs alone.
(35) Do recent studies mean that Lysenko, one of the great villains in science history, has now been vindicated by the acceptance of epigenetic inheritance
? Not really.
These new biological arguments provide a modern context suggesting that Kammerer could be the actual discoverer of epigenetic inheritance
.Ao Vargas has studied KammererAAEs evidence, as summarized in his 1920AAEs research notes, and found that Kammerer reported hybrid crosses of treated and untreated toads in which Aoparent-of-origin effectsAo can be observed, a recurrent phenomenon in epigenetics.Aa Kammerer also reported that his toads developed larger bodies than untreated land toads and that their eggs were smaller and contained less egg-yolk than normal.
The remaining 23 invited papers explore the human, mosquito, and viral factors that contribute to the global spread and persistence of dengue; the possible roles of interlinked bistable networks, epigenetic inheritance
, and bet-hedging in bacteria; and the identification and localization of base J in the genome of kinetoplastids, the enzymes involved in J biosynthesis, and possible biological functions.