(10-14) In contrast, HPV was rarely detected in extragenital SK and other non-HPV-mediated lesions on genital skin (such as fibroepithelial polyp, epidermolytic
acanthoma, and chronic dermatitis).
(10) The same team has also recently shown that the [CB.sub.1] agonist arachidonyl-2'-chloroethylamide upregulated K10 protein expression in human epidermis and reduced K1 in human skin culture thus suggesting its potential as a treatment for epidermolytic
Ichthyosis occurs due to hyperproliferation of the stratum corneum as in epidermolytic
hyperkeratosis or due to abnormal removal of the corneocytes from the skin because of as in the lamellar ichthyosis (2).
SSSS is caused by Group 2 staphylococcus epidermolytic
(exfoliative) exotoxins A and B.
junctional epidermolysis bullosa (JEB), EB simplex (EBS), ectodermal dysplasias, epidermolytic
hyperkeratosis, ectrodactyly and dyskeratosis congenita etc.16,17 Skin biopsy cells from these patients are converted to iPSC via genetic reprogramming, genetic aberration are corrected by homologous recombination, these specific iPSC are then differentiated into specific cell type followed by transplantation into the affected patient as an autograft.
Just before Ollie turned one, he was diagnosed with epidermolytic
hyperkeratosis a rare genetic skin condition which affects one in 250,000 children.
On examination, the baby was noted to have bilateral microtia along with extensive truncal and appendicular epidermolytic
lesions (Figure 1).
Bullous impetigo is the result of a staphylococcal infection, which produces an epidermolytic
toxin leading to bulla formation.
The coagulase-positive Staphylococcus aureus produces two epidermolytic
or exfoliative toxins (ETs), ETA and ETB, which induce this clinical condition.
The causative factor is an exfoliating (epidermolytic
) toxin (ET) produced by phage II Staphylococcus aureus (2).
Similar lesions have been described in one case of hereditary epidermolytic
palmoplantar keratoderma (vorner type).
Epidermal acanthosis and hyperkeratosis are histopathological characteristics that are commonly observed in chloracne (Panteleyev and Bickers 2006) and epidermolytic
hyperkeratosis, a genetic disorder associated with keratin mutations (Muller et al.