EFNB3

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EFNB3

A gene on chromosome 17p13.1 that encodes ephrin-B3, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNB3 is crucial for the development and maintenance of the brain—especially of the forebrain; it binds to, and induces the collapse of, commissural axons/growth cones, and it may play a role in the orientation of longitudinally projecting axons. It is highly expressed in brain and interacts with GRIP1 and GRIP2.
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Ephrin B2 level was elevated in the PEDF group compared to Sham (49.67%) and Saline (43.54%) groups (P < 0.05), and the ephrin B3 level was increased in the PEDF group (87.55%) compared to Sham (P < 0.05), (Figure 7(f)).
We suspected that ephrin B3 might be involved because biochemical studies have shown that it binds strongly to EphA4.
One day it may be possible for us to learn how to control the regulation of proteins, like EphA4 and ephrin B3, to encourage the directed growth to re-establish functional circuitry.