EPCAM

(redirected from Ep-CAM)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
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References in periodicals archive ?
Ep-CAM: a human epithelial antigen is a homophilic cell--cell adhesion molecule.
Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins.
Ep-CAM expression in pancreatic and ampullary carcinomas: frequency and prognostic relevance.
Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer.
We counted the number of cells stained for Ep-CAM. Dead cells were excluded from the analysis by propidium iodide staining.
The protein is called epithelial adhesion molecule (Ep-CAM).
One upregulated gene, Ep-CAM, was selected for further analysis based on its role in the intestinal epithelial cells adhesion.
The primers used for Ep-CAM were as follows: forward, 5'-TCAATGCAGGGTCTACAG-3', reverse, 5'- CCTCAAATTACGGTGTTATG-3'.
Here, we report the mapping of Ep-CAM gene that may be related to the process of adhesion of E.
Researchers found that over an average time of 10.8 years the likelihood of dying was about double for women with high levels of the sugar-protein Ep-CAM.
Survival outcomes were compared for those with and without unusually high levels of Ep-CAM.
Gastl said: 'Ep-CAM over expression could become a relevant marker for risk assessment and a target for immunotherapeutic interventions in breast cancer.'