Eosinophils


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Eosinophils

A leukocyte with coarse, round granules present.
Mentioned in: Histiocytosis X
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
These chronic and sometimes debilitating conditions are further characterized by the areas of the body in which the eosinophils have accumulated.
This 12-week biomarker study is planned to randomize approximately 100 patients with eosinophilic asthma to investigate the eosinophil response to three different doses of oral dexpramipexole.
"Eosinophils are white blood cells that secrete powerfully destructive proteins," Munitz said.
Eosinophils, which are the source of ECP, are found in nasal mucosa in allergic rhinitis (11).
Eosinophils are white-blood cells that play a central role in severe diseases such as asthma and HES, and dexpramipexole has been shown to selectively, profoundly, and persistently reduce blood and tissue eosinophil levels in multiple clinical trials.
Peripheral blood eosinophils and other non-invasive biomarkers can monitor treatment response in eosinophilic oesophagitis.
In the trial, Fasenra depleted blood eosinophils at week 12 compared with placebo, the primary endpoint of the trial, with evidence of eosinophil clearance in affected tissue at week 24.3
Researchers have found that IL-5 plays a significant part in eosinophil-mediated inflammatory reactions through its involvement in the differentiation of eosinophils from bone marrow.[3] Accordingly, biotherapeutics targeting IL-5/IL-5 receptor alpha (IL-5Ra) such as mepolizumab, reslizumab, and benralizumab were developed.
pisiformis, quantification of macrophages, lymphocytes, and eosinophils and measured of the total area of granulomas.
Postflight, significant decreases in hematocrit, tWBC, lymphocytes (abs, %), heterophils (abs), eosinophils (abs, %), and monocytes (abs) were observed.