eosinophilia-myalgia syndrome


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eosinophilia-myalgia syndrome

 
a sometimes fatal syndrome of severe myalgia associated with marked peripheral eosinophilia, associated with the ingestion of oral preparations of l-tryptophan; long-term sequelae include scleroderma and progressive neuropathy.

e·o·sin·o·phil·i·a-·my·al·gi·a syn·drome (EMS),

a probable autoimmune disorder precipitated by contaminated l-tryptophan tablets; characterized by fatigue, low-grade fever, myalgias, muscle tenderness and cramps, weakness, paresthesias of the extremities, and skin indurations; marked eosinophilia is noted on peripheral blood studies, serum aldolase is increased, and biopsies of peripheral nerve, muscle, skin, and fascia show microangiopathy and inflammation in connective tissue.
Synonym(s): E-M syndrome

e·o·sin·o·phil·i·a-my·al·gi·a syn·drome

(ē'ō-sin-ō-fil'ē-ă mī-al'jē-ă sin'drōm)
A probable autoimmune disorder precipitated by ingestion of contaminated l-tryptophan tablets, and characterized by fatigue, low-grade fever, myalgias, muscle tenderness and cramps, weakness, paresthesias of the extremities, and skin indurations; marked eosinophilia is noted on peripheral blood studies; serum aldolase is increased and biopsies of peripheral nerve, muscle, skin, and fascia show microangiopathy and inflammation in connective tissue.

eosinophilia-myalgia syndrome

A disorder featuring severe and persistent pain in the muscles, muscle weakness, loss of weight, fever, ‘pins and needles’ sensation (paraesthesia) and an exceptionally high level of EOSINOPHIL white cells in the blood. The cause is unknown but there is a strong association with ingestion of L-tryptophan.
References in periodicals archive ?
The story dates to the late 1980s, when an outbreak of an obscure illness called eosinophilia-myalgia syndrome sickened more than 1,500 people and led to at least 37 deaths.
The manufacturing error was identified and corrected relatively quickly, and there have been no reports of eosinophilia-myalgia syndrome resulting from the use of uncontaminated tryptophan.
However, some published case reports have linked tryptophan use to potentially fatal eosinophilia-myalgia syndrome. (8)
However, over-the-counter sale of this amino acid was banned in 1989, after a manufacturing error by one of the world's five L-tryptophan producers introduced a contaminant into the product that resulted in more than 1,500 of cases of eosinophilia-myalgia syndrome, including 27 deaths.
SOUTHAMPTON, BERMUDA -- Some commercially available formulations of the increasingly popular dietary supplement 5-HTP, marketed as a "safer alternative" to L-tryptophan, contain the same contaminant that was responsible for more than 1,500 cases of eosinophilia-myalgia syndrome and at least 38 deaths associated with L -tryptophan use in 1989.
SOUTHAMPTON, BERMUDA -- Some commercially available formulations of the dietary supplement 5-HTP, marketed as a "safer alternative" to L-tryptophan, contain the same contaminant that was responsible for more than 1,500 cases of eosinophilia-myalgia syndrome and at least 38 deaths associated with L-tryptophan use in 1989.
SOUTHAMPTON, BERMUDA -- Some commercially available formulations of a popular dietary supplement 5-HTP, marketed as a "safer alternative" to L-tryptophan, contain the same contaminant that was responsible for more than 1,500 cases of eosinophilia-myalgia syndrome and at least 38 deaths associated with L-tryptophan use in 1989.
FDA took action to limit the availability of L-tryptophan supplements because of the association between dietary supplements containing L-tryptophan and the 1989 epidemic outbreak of eosinophilia-myalgia syndrome (EMS) in the United States.
In the fall of 1989, the FDA recalled L-Tryptophan, an amino acid nutritional supplement, stating that it caused a rare and deadly flu-like condition (Eosinophilia-Myalgia Syndrome - EMS).
The outbreak of the disease, called eosinophilia-myalgia syndrome (EMS), was disastrous: more than 1,500 cases were reported in people taking tryptophan (an average of 1.5 grams a day), and the FDA now estimates that the actual number was 5,000.
Eosinophilia-myalgia syndrome. Results of national surveillance.