major basic protein

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major basic protein

a cytotoxic and proinflammatory mediator found in eosinophil granules.

major basic protein

An 11-kD major cytotoxic and helminthotoxic protein encoded by PRG2 on chromosome 11q12, which forms a characteristic crystalloid and is found in the granules of eosinophils and other myeloid cells. It induces non-cytolytic histamine release from human basophil, and is involved in antiparasitic defence and immune hypersensitivity reactions.

The adjectival “basic” derives from MBP’s isoelectric point of greater than pH 10. MBP is capable of killing parasites, as well as host cells; it causes bronchial epithelial damage and a wheal and flare response when injected subcutaneously, and it has been linked to asthma.
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Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complexstenosis morphology in patients with stable angina pectoris.
Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase.
Quantification and characterization of pregnancy-associated complexes of angiotensinogen and the proform of eosinophil major basic protein in serum and amniotic fluid.
Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor.
The proform of eosinophil major basic protein: a new maternal serum marker for Down syndrome.
PAPP-A is a placenta-derived glycoprotein present in circulation at term as a covalent complex with equimolar amounts of the proform of eosinophil major basic protein (proMBP), which is also synthesized in the placenta during pregnancy [191.
Identification of angiotensinogen and complement C3dg as novel proteins binding proform of eosinophil major basic protein in human pregnancy serum and plasma.

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