eosinophil cationic protein


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eosinophil cationic protein (ECP),

protein the level of which in serum of clotted blood reflects the rate of activation of circulating eosinophils.

e·o·sin·o·phil cat·i·on·ic pro·tein

(ECP) (ē'ō-sin'ō-fil kat'ī-on'ik prō'tēn)
A protein the level of which in serum of clotted blood reflects the rate of activation of circulating eosinophils.
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Eosinophil cationic protein, which was demonstrated to be a signal of bronchial asthma activity in the study of Schmekel et al.
Eosinophil cationic protein, produced by eosinophils' large secondary granules, has been developed as a marker for eosinophilic disease.
Allergy-related tests conducted by Lancet Laboratories, South Africa and Africa (2007-2011) Number of tests performed (n) 1 September 1 September 1 September 2007-31 2008-31 2009-31 Test August 2008 August 2009 August 2010 IgE 30 199 32 488 33 520 ECP 363 324 314 ImmunoCAP 201 941 244 597 258 104 ISAC N/A N/A 309 Skin-prick test 14 442 15 902 16 255 Total (N) 246 945 293 311 308 502 Number of tests performed (n) Total 1 September (1 September 2010-31 2007-31 Test August 2011 August 2011) IgE 33 641 129 848 ECP 132 1 133 ImmunoCAP 250 109 954 751 ISAC 1 854 2 163 Skin-prick test 15 999 62 598 Total (N) 301 735 1 150 493 N-A = not available; ECP = eosinophil cationic protein; ISAC = Immuno solid-phase allergen chip.
The United States as represented by the Department of Health and Human Services (Washington, DC) has patented a method for inactivating a virion of an enveloped RNA virus comprising contacting the virion with an eosinophil-derived ribonuclease, such as eosinophil-derived neurotoxin (EDN) or eosinophil cationic protein (ECP).
Nasal lavage for eosinophil count and eosinophil cationic protein (ECP) and completion of the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ, a validated instrument) were performed initially, at 2 weeks, and at 4 weeks.
In contrast, a second eosinophil RNase, the eosinophil cationic protein (RNase 3) is found only in eosinophils (5).
Eosinophil cationic protein: A new biomarker of coronary atherosclerosis.
Activated eosinophils release strong basic cytotoxic proteins such as major basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophils derived neurotoxin which are released in the conjunctiva and tear fluid and damage the conjunctival and corneal epithelium.
The eosinophils carry toxic granules which contain major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN), and eosinophil peroxidase (EPO) which are directly toxic to the larvae of Strongyloides stercoralis [3, 4].
Studies evaluating asthma exacerbations have detected a range of markers, including sputum eosinophils, peripheral blood eosinophils, serum eosinophil cationic protein, cytokines, 8-isoprostane, and leukottienes.
Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils.