enzyme inhibitor

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enzyme inhibitor

a molecule that prevents an enzyme from catalysing a reaction. Such inhibitors can compete with the normal substrate (see COMPETITIVE INHIBITION or can block the active site, preventing entry of the substrate (see NONCOMPETITIVE INHIBITION). Inhibition may be reversible or irreversible. Enzyme inhibitors often form part of a FEEDBACK MECHANISM to regulate a biochemical pathway.
References in periodicals archive ?
This includes angiotensin-converting enzyme inhibitors, angiotensin receptor blockers (sartans) and aldosterone antagonists.
Angiotensin converting enzyme inhibitors account for a type of kinin-mediated angioedema.
Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors.
Good evidence exists to support the use of key secondary prevention medications (a four-drug combination of aspirin, statins, beta-blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) and smoking cessation in patients after acute coronary syndromes (ACSs).
Evaluation of enzyme inhibitors in drug discovery; a guide for medicinal chemists and pharmacologists, 2d ed.
Page 245-250/Sayfa 245-250: The effects of chronic usage of enzyme inhibitors and angiotensin receptor blockers on contrast-induced nephropathy in low-risk patients Nezihi Baris, Ebru Ozpelit, Nazile Bilgin Dogan, Hande Kangul, Sefa Gul, Bahri Akeniz, Sema Guneri
Our vision is to provide fundamental structural and mechanistic-dissection of key proteins and their complexes and to use these as the foundation to deliver enzyme inhibitors as tools to probe the cellular function of specific glycans.
Researchers sought to determine whether enzyme inhibitors could reduce shock rates.
All of these therapies--angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, beta-adrenergic blocking agents (betablockers), aldosterone antagonists, hydralazine/ isosorbide dinitrate, implantable cardioverter defibrillators, and cardiac resynchronization therapy--are effective in treating heart failure, with the benefits outweighing the risks.
Objective: To compare efficacy of calcium channel blockers (CCBs) with angiotensin converting enzyme inhibitors (ACEIs) in the treatment of elderly men (age more than 55 years) with essential hypertension.
The other two volumes in the series treat enzyme technologies in drug discovery, and the design of enzyme inhibitors for therapeutics.