enzyme inhibitor

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enzyme inhibitor

a molecule that prevents an enzyme from catalysing a reaction. Such inhibitors can compete with the normal substrate (see COMPETITIVE INHIBITION or can block the active site, preventing entry of the substrate (see NONCOMPETITIVE INHIBITION). Inhibition may be reversible or irreversible. Enzyme inhibitors often form part of a FEEDBACK MECHANISM to regulate a biochemical pathway.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Chronic cardiac failure (mild to moderate) for which administration of angiotensin converting enzyme inhibitors is not appropriate
Withholding angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) 24 hours before noncardiac surgery has been associated with a 30-day lower risk for all-cause death, stroke, myocardial injury, and intra operative hypotension (18% adjusted relative risk reduction).
In an attempt to reduce nitrogen (N) losses through ammonia volatilization and nitrate leaching, the use of enzyme inhibitors (EI) such as N-(n-butyl) thiophosphoric triamide (NBPT) and dicyandiamide (DCD) has been shown to be viable (Zaman et al., 2009; Dall'Orsoletta et al., 2017).
30, 2018 (HealthDay News) -- The use of angiotensin-converting enzyme inhibitors (ACEIs) is associated with an increased risk for lung cancer compared with angiotensin receptor blockers, according to a study published online Oct.
"Associations were evident after five years of use and increased with longer durations of use, particularly in patients who used angiotensin converting enzyme inhibitors for more than 10 years."
His most recent role has seen him serve as EVP of Research & Development and CMO of Mission Therapeutics Ltd, where he was responsible for developing the company's pipeline of deubiquitinating enzyme inhibitors.
The review included medications from the five main classes of antihypertensives, including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, calcium channel blockers and thiazides.
Fiskio et al., "An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors," Journal of Evaluation in Clinical Practice, vol.
Angioedema is a well-known side effect of angiotensin converting enzyme inhibitors (ACEi).
The topics include ligand-based drug design, drug-like properties and decision making in medicinal chemistry, in vivo imaging in drug discovery, peptide and protein drug design, enzyme inhibitors: biostructure-based and mechanism-based design, ion channels: structure and function, acetylcholine, dopamine and serotonin, opioid and cannabinoid receptors, targeting receptor tyrosine kinases, and antibiotics.
Angioedema induced by angiotensin-converting enzyme inhibitors. Curr Opin Allergy Clin Immunol.