(redirected from Endothelin-3)


A 21-amino acid peptide originally derived from endothelial cells. It is an extremely potent vasoconstrictor. Three different gene products have been identified, endothelin 1, endothelin 2, and endothelin 3; they are found in brain, kidney, and endothelium (endothelin 1), intestine (endothelin 2), and intestine and adrenal gland (endothelin 3).

endothelin (ET)

any of a group of vasoconstrictive peptides produced by endothelial cells. Three known endothelins, designated ET-1, ET-2, and ET-3, are chemically related to asp venom. ET-1 is the most potent vasoconstrictor yet discovered, being 10 times stronger than the second-most potent vasoconstrictor known, angiotensin II.


powerful vasodilatory chemical, released by vascular endothelium


see endothelium-derived constricting factor.
References in periodicals archive ?
Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries.
ETs are a family of peptide hormones with three members, endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3) (Inoue et al.
Cross-reactivity of the system for endothelin-1 is 100%, but less than 7% for both endothelin-2 and endothelin-3 according to the manufacturer.
Japanese patients with sporadic Hirschsprung: mutation analysis of the receptor tyrosine kinase proto-oncogene, endothelin-B receptor, endothelin-3, glial cell line-derived neurotrophic factor and neurturin genes: a comparison with similar studies.
Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease.
Until now, three isoforms, endothelin-1, endothelin-2, and endothelin-3, have been isolated, each consisting of 21 amino acid residues [2].
Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary fibroblasts.

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