endothelin(redirected from Endothelin-2)
A 21-amino acid peptide originally derived from endothelial cells. It is an extremely potent vasoconstrictor. Three different gene products have been identified, endothelin 1, endothelin 2, and endothelin 3; they are found in brain, kidney, and endothelium (endothelin 1), intestine (endothelin 2), and intestine and adrenal gland (endothelin 3).
any of a group of vasoconstrictive peptides produced by endothelial cells. Three known endothelins, designated ET-1, ET-2, and ET-3, are chemically related to asp venom. ET-1 is the most potent vasoconstrictor yet discovered, being 10 times stronger than the second-most potent vasoconstrictor known, angiotensin II.
see endothelium-derived constricting factor.