endothelin-1

EDN1

A gene on chromosome 6p24.1 that encodes endothelin 1, a potent vasoconstrictor of the endothelin family, which is produced by vascular endothelial cells.

endothelin-1

A peptide of 21 amino acids produced by the endothelial cells of arteries that has a powerful arterial tightening (vasoconstrictor) function. It also induces MITOSIS in cells. It has a short half-life of 1–2 minutes and its production is inhibited by endothelial-derived relaxing factor and stimulated by ANGIOTENSIN II, vasopressin, and thrombin.
References in periodicals archive ?
Endothelin-1 (ET-1) is mainly related to endothelial dysfunction, but other cells are also capable of producing the ET-1, such as vascular smooth muscle cells and mesangial cells of the kidney (11).
Blood concentrations of nitric oxide, endothelin-1 and endothelial nitric oxide synthase were measured on days 1-3 and 5-7 of the neonatal period.
Effects of endothelin-1 on vascular tension in human umbilical vessels.
4) Although the etiopathogenesis of the disease is not fully understood, increased endothelin-1 activity has been considered to have a role in the pathogenesis of the vascular component.
Digital ulcers occur in 35%-68% of systemic sclerosis patients, and endothelin-1 (ET-1) has demonstrated overexpression in the plasma of these patients, wrote Dr.
In the past decade, endothelin-1 (ET-1) was identified as an important factor among vasoactive factors contributing to the onset and progression of proteinuria.
Many authors demonstrated that endothelin-1 (ET-1), a vasoconstrictive, endothelial peptide, accelerates ROS formation in vascular smooth muscle cells (VSMC), endothelial cells, and other tissues [13-15].
In contrast to this, our study aimed to unveil the correlation of lipid profile to the two contrasting vascular biomarkers that is endothelin-1 (ET-1) as vasoconstrictor versus nitric oxide (NO) as vasodilator in apparently healthy overweight/obese & non-obese subjects and not in cases of established chronic vascular disease.
Five others describe endothelin-1 (ET-1) and interleukin-6 (IL-6) biomarkers, and discoveries for their implications in heart disease and its comorbidities.
In other research Baqrabadi and colleagues (13, 2011) investigated impact of regular aerobic exercise on amount of endothelin-1 of concentration in older women and found that endothelial function is impaired by aging.
The molecule, Endothelin-1 (ET-1), is shown to inhibit repair of myelin.

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