Arita et al., "Novel modulator for endothelial adhesion molecules
: adipocyte-derived plasma protein adiponectin," Circulation, vol.
Endothelial adhesion molecules
are associated with inflammation in subjects with HIV disease.
Hamid, "Effect of intranasal fluticasone on cellular infiltration, endothelial adhesion molecule
expression, and proinflammatory cytokine mRNA in nasal polyp disease," Journal of Allergy and Clinical Immunology I, vol.
As an endothelial adhesion molecule
involved in leukocyte recruitment under inflammatory conditions, VAP-1 was recently showed to contribute to the recruitment of macrophages to CNV lesions in a rat laser-induced AMD model and had a novel link with angiogenesis .
The reasons for such correlating relationship between the endothelial adhesion molecules
, leukocytes and exercise intensity could be multi factorial.
Altered expression of endothelial adhesion molecules
is achieved by two mechanisms, one involving histamine (as well as thrombin, and reactive oxygen species), and the other the cytokines, especially IL-1beta and TNF.
Circulating levels of endothelial adhesion molecules
and risk of diabetes in an ethnically diverse cohort of women.
Nevertheless, cocoa treatment did not significantly reduce blood pressure or improve insulin resistance, and had no significant effects on skeletal muscle capillary recruitment, circulating plasma concentrations of adipocytokines, or endothelial adhesion molecules
. Therefore, researchers believe daily consumption of flavanol-rich cocoa for 2 weeks is not sufficient to reduce blood pressure or improve insulin resistance in human subjects with essential hypertension.
In addition to its capacity to induce and maintain vasodilatation, nitric oxide is antiatherogenic by virtue of its ability to reduce the oxidation of low-density lipoproteins, platelet aggregability, smooth muscle cell proliferation, and the expression of endothelial adhesion molecules
. Adhesion molecules promote the binding and rolling of inflammatory cells (monocytes, T-lymphocytes) along stressed endothelium, and include such molecules as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1).
Cytokine-induced expression of endothelial adhesion molecules
ICAM-1 and VCAM-1 under the influence of garlic (Allium sativum).
"Antioxidant agents might protect against oxidant-related upregulation of endothelial adhesion molecules
and slow down the progression of vascular damage in non-insulin dependent diabetes."
Also, Gln supplementation reduced gene expressions of endothelial adhesion molecules
in colons, prevented BW loss, and attenuated colon edema in colitic mice.