endopeptidase

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Related to Endopeptidases: Exopeptidases

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

en·do·pep·ti·dase

(en'dō-pep'ti-dās),
An enzyme that catalyzes the hydrolysis of a peptide chain at points well within the chain, not near either terminus; for example, pepsin, trypsin. Compare: exopeptidase.
Synonym(s): proteinase

endopeptidase

/en·do·pep·ti·dase/ (-pep´tĭ-dās) protease; any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein.

endopeptidase

(ĕn′dō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.

endopeptidase

[en′dōpep′ti·dās]
Etymology: Gk, endon, within + Gk, peptein, to digest + ase, enzyme suffix
any peptidase that catalyzes the cleavage of internal peptide bonds in a polypeptide or protein. Endopeptidases are divided into subclasses on the basis of catalytic mechanism and comprise the serine endopeptidases, cysteine endopeptidases, aspartic endopeptidases, metalloendopeptidases, and other endopeptidases.

en·do·pep·ti·dase

(en'dō-pep'ti-dās)
An enzyme catalyzing the hydrolysis of a peptide chain at points well within the chain, not near termini (e.g., pepsin, trypsin).
Compare: exopeptidase

endopeptidase

or

proteinase

a type of PROTEASE (protein-splitting enzyme) that hydrolyses peptide bonds between particular amino acids located inside the chain, but not at the ends. There are three major endopeptidases in the mammalian gut: PEPSIN (stomach); TRYPSIN and CHYMOTRYPSIN (pancreas). Such enzymes are responsible for the first stage of protein digestion; other proteases called EXOPEPTIDASES complete the digestion of protein in the ILEUM.

endopeptidase

a peptidase capable of acting on any peptide linkage in a peptide chain.
References in periodicals archive ?
The purification and specificity of a neutral endopeptidase from rabbit kidney brush border.
55) Experiments using a panel of more than 20 peptidase inhibitors highlighted that a neutral endopeptidase family member, similar or identical to neprilysin, appears to play a major role in the A[[beta].
Non-proteasome proteases have been divided into exopeptidases and endopeptidases depending on the cleavage position of target proteins.
The most common form is inherited in an X-linked dominant manner (XLH), associated with mutations in the PHEX gene (Phosphate regulating gene with Homologies to Endopeptidases on the X-chromosome) [Feng, 2006; Lorenz-Depiereux et al.
The function of L chains has been established as zinc dependent endopeptidases (77), and the substrates are one of the three proteins of the docking complex responsible for release of acetylcholine from synaptic vesicles.
Key words: Lambda-cyhalothrin, Periplaneta americana, cytoplasmic proteases, lysosomal proteases, aminopeptidases, endopeptidases, cathepsins.
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components.
5) Exenatide is cleared by glomerular filtration (and is thus contraindicated in patients with severe renal disease), whereas liraglutide is metabolized by endopeptidases and undergoes hepatic or renal metabolism.
No caso da pancreatina, este resultado poderia ser explicado pelo fato de que trata-se de um complexo enzimatico que apresenta tanto endopeptidases (tripsina, quimiotripsina) como exopeptidases (carboxipeptidase A e B) sendo, portanto, capaz de hidrolisar ligacoes peptidicas tanto no interior quanto nas porcoes Nou C- terminais da cadeia peptidica.
The whey protein used in the study, however--Optipep--uses specific exo- and endopeptidases to reduce bitterness.
These abnormalities are more prominent in strains lacking DD-carboxypeptidase (PBP 5) along with endopeptidases (PBPs 4 and 7).