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For metastatic CCRCC to the pancreas, the differential diagnoses include ductal adenocarcinoma with clear cell appearance (clear cell carcinoma), clear cell endocrine pancreatic tumor, solid serous adenoma of the pancreas, clear cell variant of solid pseudopapillary tumor of the pancreas, and perivascular epithelioid cell tumor (PEComa).
Clear cell endocrine pancreatic tumor, particularly in the setting of von Hippel-Lindau disease, is known to closely mimic metastatic CCRCC, because tumor cells in this group of neoplasm may be arranged in cords, nests, and tubules, all of which can be seen with central hemorrhage, simulating CCRCC.
Somatostatinoma--Somatostatinoma is the most rare endocrine pancreatic tumor (<1%) and, at the time of diagnosis, most are malignant (75%).
Endocrine pancreatic tumors, formally known as islet cell tumors, are benign or malignant neoplasms with endocrine cell differentiation.
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients.
Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization.
The clinical manifestation of nonfunctioning endocrine pancreatic tumors is characterized by nonspecific symptoms.
Using routine histopathological methods, non-functioning endocrine pancreatic tumors cannot be differentiated from functional tumors.
Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients.
Endocrine pancreatic tumors in von Hippel-Lindau disease: clinical, histological, and genetic features.
For endocrine carcinomas, data were obtained only from cases recorded from 1992 to 2005 in SEER (Registry 13) because the 1992 edition of the ICD-O specifically included codes for endocrine pancreatic tumors.
Endocrine pancreatic tumors are morphologically, functionally, and biologically different from tumors of the ductal epithelium.