endocrine disruptor

(redirected from Endocrine Disrupting Compound)

endocrine disruptor

A substance which interferes with the synthesis, secretion, transport, binding, action or elimination of natural hormones in the body that are responsible for development, behaviour, fertility and maintenance of homeostasis (normal cell metabolism).

Examples
DDT, polychlorinated biphenyls, bisphenol A, polybrominated diphenyl ethers, phthalates.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

endocrine disruptor

(dĭs-rŭp′tĕr)
A chemical that may imitate or block the function of natural hormones if it is absorbed by the body. Many pesticides and plasticizing compounds, e.g., phthalates, are thought to disrupt endocrine pathways, esp. if they are absorbed by pregnant women during embryonic and fetal development.
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
DEHP represents a particular public health concern because 100% of the US population have measurable levels of this endocrine disrupting compound. Phthalates have been found to be associated with significantly earlier menopause in women, decreased couple fecundity, low birth weight, preterm birth, altered placental methylome and transcriptome, and pregnancy loss.
An endocrine disrupting compound (EDC) can be defined as "an exogenous agent that interferes with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for the maintenance of homeostasis, reproduction, development, and/or behavior" (Kavlock et ah, 1996).
Removal mechanisms for endocrine disrupting compounds (EDCs) in wastewater treatment-physical means, biodegradation, and chemical advanced oxidation: A review, Science of the Total Environment, 407: 731-748.
Endocrine disrupting compounds (EDCs) that mimic sex steroid hormones are of particular concern and have the potential to alter the reproductive physiology of teleost fishes.
Endocrine disrupting compounds (EDCs) constitute an important class of emerging environmental contaminants, which pose an increasing threat to aquatic organisms, as well as to human health [1].
Health effects attributed to endocrine disrupting compounds include a range of reproductive problems (reduced fertility, male and female reproductive tract abnormalities, and skewed male/female sex ratios, loss of fetus, menstrual problems); changes in hormone levels; early puberty; brain and behavior problems; impaired immune functions; and various cancers.
Disruption of androgen biosynthesis and actions by environmental endocrine disrupting compounds can inhibit critical cellular processes controlling steroidogenesis in the Leydig cells.
Analysis of endocrine disrupting compounds in food.
Endocrine disrupting compounds are being detected at greater frequency in municipal water.
The institute, which is associated with the Harvard School of Public Health, conducted tests on water supplies for 16 pharmaceuticals, six known or suspected endocrine disrupting compounds, two flame retardants, a fragrance and an insect repellent.
Based on understandings from the new field of epigenetics, endocrine disrupting compounds interact with the body's endocrine signalling systems in a way that makes not only dosage but also timing critical in determining the effects of exposure.

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