bisoprolol fumarate

(redirected from Emcor)
Also found in: Wikipedia.

bisoprolol fumarate

Apo-Bisoprolol, Bisoprolol (CA), Cardicor (UK), Emcor (UK), Emcor LS (UK), Monocor (CA), Novo-Bisoprolol (CA), PMS-Bisoprolol (CA), Sandoz Bisoprolol (CA), Zebeta

Pharmacologic class: Beta1-adrenergic blocker

Therapeutic class: Antihypertensive

Pregnancy risk category C


Blocks beta1-adrenergic receptors of sympathetic nervous system in heart and kidney, thereby decreasing myocardial excitability, myocardial oxygen consumption, cardiac output, and renin release from kidney. Also lowers blood pressure without affecting beta2-adrenergic (pulmonary, vascular, and uterine) receptor sites.


Tablets: 5 mg, 10 mg

Indications and dosages


Adults: Initially, 2.5 to 5 mg P.O. daily. Dosages up to 20 mg P.O. daily have been used.

Dosage adjustment

• Renal or hepatic impairment


• Hypersensitivity to drug
• Sinus bradycardia
• Second- or third-degree heart block
• Cardiogenic shock
• Heart failure
• Children (safety and efficacy not established)


Use cautiously in:
• renal or hepatic impairment, pulmonary disease, asthma, diabetes mellitus, thyrotoxicosis, peripheral vascular disease
• patients undergoing anesthesia or major surgery
• elderly patients
• pregnant or breastfeeding patients.


• Give with or without food, but be consistent to minimize variations in absorption.
• Be aware that drug may be given alone or added to diuretic therapy.

Adverse reactions

CNS: dizziness, depression, paresthesia, sleep disturbances, hallucinations, memory loss, slurred speech

CV: bradycardia, peripheral vascular insufficiency, claudication, hypotension, sinoatrial or atrioventricular (AV) node block, second- or third-degree heart block, heart failure, pulmonary edema, cerebrovascular accident, arrhythmias

EENT: blurred vision, dry eyes, conjunctivitis, tinnitus, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, gastric pain, gastritis, flatulence, anorexia, ischemic colitis, acute pancreatitis, renal and mesenteric arterial thrombosis

GU: dysuria, polyuria, nocturia, erectile dysfunction, Peyronie's disease, decreased libido

Hematologic: eosinophilia, agranulocytosis, thrombocytopenia

Hepatic: hepatomegaly

Metabolic: hyperglycemia, hypoglycemia

Musculoskeletal: arthralgia, muscle cramps

Respiratory: dyspnea, cough, bronchial obstruction, bronchospasm

Skin: rash, purpura, pruritus, dry skin, excessive sweating


Drug-drug.Amphetamines, ephedrine, epinephrine, norepinephrine, phenylephrine, pseudoephedrine: unopposed alpha-adrenergic stimulation

Antihypertensives: increased hypotension

Digoxin: additive bradycardia

Dobutamine, dopamine: decrease in beneficial beta1-adrenergic cardiovascular effects

General anesthetics, I.V. phenytoin, verapamil: additive myocardial depression

MAO inhibitors: hypertension (when taken within 14 days of bisoprolol)

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effect

Thyroid preparations: decreased bisoprolol efficacy

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, glucose, low-density lipoproteins,

potassium, uric acid: increased levels

Antinuclear antibodies: increased titers

Insulin tolerance test: test interference

Drug-behaviors.Acute alcohol ingestion: additive hypotension

Cocaine use: unopposed alpha-adrenergic stimulation

Patient monitoring

• Closely monitor blood glucose levels in diabetic patients.
• Assess for signs and symptoms of heart failure, including weight gain.
• Stay alert for blood pressure variations. Low blood pressure may indicate overdose.

Patient teaching

• Tell patient to weigh himself daily at same time and to report gain of 3 to 4 lb/day.
• Instruct patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from blood pressure decrease.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to restrict salt intake to help avoid fluid retention.
• Caution patient not to discontinue drug abruptly unless prescriber approves.
• Tell patient to carry medical identification stating that he's taking a beta blocker.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

bisoprolol fumarate (bis´ōprō´lol fyōō´mərāt´),

n brand name: Zebeta;
drug class: antihypertensive, selective β1 blocker;
action: produces fall in blood pressure without reflex tachycardia or significant reduction in heart rate;
uses: treatment of hypertension as a single agent or in combination.
Mentioned in ?
References in periodicals archive ?
Caption: EMCOR/F&G Mechanical announced its employees, along with those of Tishman Construction, an AECOM Company, Tucker Development, and several dozen other supporters donned EMCOR Pink Hard Hats and assembled to form EMCOR's signature giant human pink ribbon in a "Call to Action" in support of breast cancer awareness as part of the Company's EMCOR's 7th Annual "Protect Yourself.
3, 2014 /PRNewswire/ -- Emcor Enclosures, a business unit of Crenlo, will debut its new Guardian[sup.
Illingworth-Kilgust Mechanical proudly announces that its construction workers at various job sites are wearing EMCOR Pink Hard Hats throughout October, Breast Cancer Awareness Month, as a "Call to Action" supporting breast cancer screening and awareness as part of EMCOR's "Protect Yourself.
Summary: In a significant development, EMCOR Facilities Services (Bahrain) W.
We're honored at NASA's recognition of EMCOR Government Services as a leader in operations and maintenance services," stated Michael Shelton, Chairman and CEO, EGS.
As part of its program, EMCOR and its clients are forming giant human Pink Hard Hat Ribbons, EMCOR s signature event, in six locations across the U.
EMCOR Group, Inc, a Fortune 500 leader in mechanical and electrical construction, energy infrastructure and facilities services for a diverse range of businesses, announced that it had acquired Team Mechanical, Inc.
A leading facilities services and construction contractor in the Midwest, Shambaugh & Son is a subsidiary of EMCOR Group, Inc.
Since 2004, CNA Risk Control has worked with EMCOR to help manage EMCOR's risk exposure.
21 /PRNewswire/ -- PECO Energy Company (NYSE: PE) has formed a strategic alliance with EMCOR Facilities Services, Inc.
EMCOR Government Services is pleased to have been selected by the Army to provide a diverse range of services required to support the Directorate of Public Works at Fort Huachuca," stated Michael Shelton, Chairman and CEO, EMCOR Government Services.