preimplantation genetic diagnosis

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preimplantation genetic diagnosis

In assisted reproduction, the testing of a fertilized egg for heritable illnesses before the ovum is inserted into the female.
See also: diagnosis

preimplantation genetic diagnosis

The use of genetic analysis in the course of vitro fertilization to ensure that a baby does not possess a known genetic defect of either parent. After analysis of the embryos formed, only those free of defect are implanted in the mother's womb. A new method, developed in 2006, involves taking a single cell from the IVF embryo, amplifying the entire genome to provide many copies, and then comparing the chromosome containing the known family mutation with those of other family members by standard DNA fingerprinting techniques.
References in periodicals archive ?
Embryo biopsy was performed on day 5 or 6 for chromosomal analysis using Next Generation Sequensing (NGS) method.
Embryo biopsy was performed on d3, although we had previously demonstrated a high correlation between the results obtained on d3 or d5 after biopsy even though the array-CGH protocol for PGS is used [32].
In the same year, Alison Campbell form Manchester introduced a new method called time-lapse imaging for early discovery of a damaged embryo without the need for the use of embryo biopsy or the previously mentioned PGD [2].
Based on the current results, it seems, at least in term of hatching process the bovine embryos are more tolerable to embryo biopsy and vitrification compared with ovine embryos.
Eight-cell stage mouse embryos were biopsied, using a single-cell embryo biopsy technique, similar to the one used in pre-implantation diagnosis of genetic defects (l).
(14) Embryo biopsy negatively affects the implantation rate of embryos; in other words, couples using IVF for infertility decrease their chances of success if they add on PGD in order to choose a genetic trait.
Tellingly, the crucial contemporary interface between medical technology and the video display terminal can be seen in the now commonplace short films of manipulated embryos featuring micro-injection, embryo biopsy, and somatic cell nuclear transfer.
Single-cell embryo biopsy to detect disease-causing genes or chromosomal abnormalities is called pre-implantation genetic diagnosis (PGD).
The plan also calls for aggressively pursuing an assessment of the potential of alternative sources of pluripotent stem cell lines, including altered nuclear transfer; single cell embryo biopsy, and reprogramming, or dedifferentiation of somatic cells, such as skin cells.
In addition, such a possibility would likely preclude federal funding for producing stem cell lines from such cells because of restrictions contained in the Dickey Amendment (see subsection, below, Embryo Biopsy).
After the assisted reproduction techniques have been applied, an embryo biopsy is conducted, extracting two of the blastomeres, which are genetically analyzed.
Embryo biopsy is performed to obtain the single cell necessary for evaluating and assessing genetic risk.