The main findings of this study were that the terminal elimination half-life
of cervical epidural-administered triamcinolone acetonide in a non-compartmental analysis was 219 hours, and the peak triamcinolone concentration of 5.4ng/mL was detected within 22.1 hours after administration.
The values for elimination rate constant, elimination half-life
, and MRT were 0.105 0.003l/hrs, 6.654 0.164 hrs and 8.403 0.127 hrs respectively20 in a study performed in Pakistani population with 40mg of atorvastatin, which are also in accordance to the values in present study.
Plasma protein binding is an average 93%, and the elimination half-life
is less than 2 hours.
The elimination half-life
in animals treated with the IM-DQ in microsuspension was estimated to be 1.65-fold longer than the elimination half-life
observed in animals treated with IM-DQ nanosuspension.
The longer elimination half-life
of marbofloxacin observed in this study reflects the advantage of this drug in maintaining effective concentration in the body thereby allowing longer time for drug-pathogen interaction.
In those patients, the elimination half-life
can be increased up to 13 hours.
of cefpirome in lungs was highest followed by heart, liver, kidney, and spleen while its plasma half-life [t.sub.1/2] in plasma was very low suggesting more affinity of cefpirome in tissues in comparison to blood.
Its elimination half-life
is 5 to 6 hours (Lexicomp).
To understand how to calculate elimination half-life
using graphical log concentration versus time as well as by using mathematical method.
Additionally, the elimination half-life
of some drugs may increase with age because of larger volumes of distribution and reduction in hepatic or renal clearance.
No residual interference was observed, because iomeprol has an elimination half-life
of 89-129 min.
 investigated the efficacy of new erythropoietic agents, with polyethylene glycol (PEG) conjugated proteins in rats with chronic renal insufficiency, which can prolong elimination half-life
time and diminish protein immunogenicity.