biological half-life

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biological half-life

n.

biological half-life

the time required for the body to eliminate half of an administered dose of any substance by regular physiological processes. The biological half-life is approximately the same for stable and radioactive isotopes of a specific element. Also called metabolic half-life. See also effective half-life, half-life.
Biology The time required for one half of the total amount of a particular substance in a biological system to be degraded by biological processes when the rate of removal is nearly exponential
Nuclear physics The length of time required for one half of a radioactive substance to be biologically eliminated from the body

biological half-life

T1/2 Biology The time required for 1⁄2 of the total amount of a particular substance in a biologic system to be degraded by biological processes when the rate of removal is nearly exponential Radiation physics The length of time required for1/2 of a radioactive substance to be biologically eliminated from the body
References in periodicals archive ?
However, the drug has a long elimination half-life (about 19 days), so, depending on when it was given, it could cross in late pregnancy.
Diazepam has a peak concentration of about 2 hours, but a much longer elimination half-life - up to 48 hours in a healthy adult and up to 80 hours in an elderly person.
A long elimination half-life may lead to increased drug exposure and unwanted side effects such as residual daytime drowsiness.
Terminal elimination rate constant (Ke) was determined by linear regression of the terminal portion of the plasma concentration-time data, and the elimination half-life ([t.
The suggestion that Intuniv has a short elimination half-life also was incorrect.
2) Children <12 years old have a smaller area under the Cmax curve (AUC), a faster clearance and a shorter elimination half-life than adults.
The half-life [beta] is 30-60 minutes, but a third compartment with slower elimination half-life is also present, indicating the possibility of accumulation after very long infusions.
Similarly, the categorization of antimalarial treatment group by terminal elimination half-life could have been worked out, had it been done on data obtained from only in low transmission areas.
Pharmacologically, amiodarone has high lipid solubility, a large volume of distribution, and an elimination half-life ranging from 40 to 60 days.
0-[infinity]], serum elimination half-life, time to reach peak serum concentration, elimination rate constant, and mean resident time did not change significantly.
Poor metabolizers have an 80% increase in drug exposure and twice the elimination half-life, compared with extensive metabolizers, placing them at increased of adverse drug reactions.

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