biological half-life

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biological half-life

n.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
Biology The time required for one half of the total amount of a particular substance in a biological system to be degraded by biological processes when the rate of removal is nearly exponential
Nuclear physics The length of time required for one half of a radioactive substance to be biologically eliminated from the body
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

biological half-life

T1/2 Biology The time required for 1⁄2 of the total amount of a particular substance in a biologic system to be degraded by biological processes when the rate of removal is nearly exponential Radiation physics The length of time required for1/2 of a radioactive substance to be biologically eliminated from the body
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The main findings of this study were that the terminal elimination half-life of cervical epidural-administered triamcinolone acetonide in a non-compartmental analysis was 219 hours, and the peak triamcinolone concentration of 5.4ng/mL was detected within 22.1 hours after administration.
The values for elimination rate constant, elimination half-life, and MRT were 0.105 0.003l/hrs, 6.654 0.164 hrs and 8.403 0.127 hrs respectively20 in a study performed in Pakistani population with 40mg of atorvastatin, which are also in accordance to the values in present study.
Plasma protein binding is an average 93%, and the elimination half-life is less than 2 hours.
The elimination half-life in animals treated with the IM-DQ in microsuspension was estimated to be 1.65-fold longer than the elimination half-life observed in animals treated with IM-DQ nanosuspension.
The longer elimination half-life of marbofloxacin observed in this study reflects the advantage of this drug in maintaining effective concentration in the body thereby allowing longer time for drug-pathogen interaction.
In those patients, the elimination half-life can be increased up to 13 hours.
Elimination half-life of cefpirome in lungs was highest followed by heart, liver, kidney, and spleen while its plasma half-life [t.sub.1/2] in plasma was very low suggesting more affinity of cefpirome in tissues in comparison to blood.
To understand how to calculate elimination half-life using graphical log concentration versus time as well as by using mathematical method.
Additionally, the elimination half-life of some drugs may increase with age because of larger volumes of distribution and reduction in hepatic or renal clearance.
No residual interference was observed, because iomeprol has an elimination half-life of 89-129 min.
[15] investigated the efficacy of new erythropoietic agents, with polyethylene glycol (PEG) conjugated proteins in rats with chronic renal insufficiency, which can prolong elimination half-life time and diminish protein immunogenicity.

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