However, the drug has a long elimination half-life
(about 19 days), so, depending on when it was given, it could cross in late pregnancy.
Diazepam has a peak concentration of about 2 hours, but a much longer elimination half-life
- up to 48 hours in a healthy adult and up to 80 hours in an elderly person.
A long elimination half-life
may lead to increased drug exposure and unwanted side effects such as residual daytime drowsiness.
The tapering plan should involve one drug at a time and reduce the drug with the longest elimination half-life
Terminal elimination rate constant (Ke) was determined by linear regression of the terminal portion of the plasma concentration-time data, and the elimination half-life
The suggestion that Intuniv has a short elimination half-life
also was incorrect.
2) Children <12 years old have a smaller area under the Cmax curve (AUC), a faster clearance and a shorter elimination half-life
The half-life [beta] is 30-60 minutes, but a third compartment with slower elimination half-life
is also present, indicating the possibility of accumulation after very long infusions.
Similarly, the categorization of antimalarial treatment group by terminal elimination half-life
could have been worked out, had it been done on data obtained from only in low transmission areas.
Pharmacologically, amiodarone has high lipid solubility, a large volume of distribution, and an elimination half-life
ranging from 40 to 60 days.
0-[infinity]], serum elimination half-life
, time to reach peak serum concentration, elimination rate constant, and mean resident time did not change significantly.
Poor metabolizers have an 80% increase in drug exposure and twice the elimination half-life
, compared with extensive metabolizers, placing them at increased of adverse drug reactions.