electrophile

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electrophile

 [e-lek´tro-fīl]
a chemical compound that serves as an electron acceptor in a chemical reaction. adj., adj electrophil´ic.

e·lec·tro·phil

, electrophile (ē-lek'trō-fil, -fīl),
1. The electron-attracting atom or agent in an organic reaction. Compare: nucleophil.
2. Relating to an electrophil. Synonym(s): electrophilic
[electro- + G. philos, fond]

e·lec·tro·phil

, electrophile (ĕ-lek'trō-fil, -fīl)
1. The electron-attracting atom or agent in an organic reaction.
Compare: nucleophil
2. Relating to an electrophil.
Synonym(s): electrophilic.
[electro- + G. philos, fond]
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References in periodicals archive ?
This fact can be attributed to the greater number of furan groups present in these compounds which are able to increase the cross-linked density in the polymers since their unsubstituted 5-position is electronically activated for electrophilic substitutions.
In particular, the oxygen atoms [O.sub.23] and [O.sub.18] in each complex (with electrostatic potentials ranging from -0.1537 au in D to -0.14337 au in B) are found to be the most suitable sites for electrophilic attack.
The analysis of Table 5 shows that carbon C (10) is the probable site for nucleophilic attacks, whereas carbon C (14) is the probable site for electrophilic attacks.
We hypothesized that LIM is metabolized to an electrophilic species, a cis-enedial intermediate, then reactive with the nucleophilic side residues of proteins (thiol, alcohol, phenol, carboxyl, and amine), and led to the inactivation of protein functions.
Finally, the condensed electrophilic and nucleophilic Parr functions [P.sup.+.sub.k] and [P.sup.-.sub.k] over the atoms of the dansylglycine molecule in water and in dioxane have been calculated by extracting the Mulliken and Hirshfeld (or CM5) atomic charges using the Chemcraft molecular analysis program [38] starting from single-point energy calculations of the ionic species with the MN12SX density functional using the Def2TZVP basis set in the presence of the solvents according to the SMD solvation model.
Each ASD gathered at different atoms of the radical cation and the radical anion of a molecule provides the local nucleophilic [P.sub.k.sup.-] and electrophilic [P.sub.k.sup.+] parr functions of the neutral molecule.
(68) Specific Cys residues of TRPA1 are capable of reacting with many of these compounds via electrophilic Michael addition.
Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.
It plays an important role in detoxification by catalyzing the conjugation of many drophobic and electrophilic compounds with reduced glutathion.
Samples of nineteen chapters are: general concepts for covalent bonding and constructing Lewis structures for organic molecules; guideline for writing organic molecule isomers and determining number of rings plus pi-bonds; notation in organic chemistry; guide to writing and using condensed formulas and line drawings; summary guidelines for organic nomenclature; summary guide to thermodynamic concepts for organic chemistry; guide to stereochemistry concepts and analysis of reaction stereochemistry as applied to electrophilic addition; a brief guideline for applying fundamental concepts in NMR spectroscopy.
Some drugs are metabolized and converted into active toxic metabolites under the action of CYP450, such as electrophilic group, free radical, and oxygroup, which can covalently bind macromolecular substances including protein, nucleic acid, and lipid, causing lipid peroxidation and final hepatocyte necrosis.[sup][12]
Chemical-quantum descriptors enable us to know the nucleophilic or electrophilic nature of a molecule globally or locally on a relative scale [96, 97 g].