electroporation

(redirected from Electropermeabilization)
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e·lec·tro·por·a·tion

(ē-lek'trō-pōr-ā'shŭn),
A technique in which a brief electric shock is applied to cells; momentary holes open briefly in the plasma membrane, allowing the entry of macromolecules (for example, a way of introducing new DNA into a cell).

electroporation

(ĭ-lĕk′trō-pə-rā′shən)
n.
A process of applying a high-voltage electrical pulse to a living cell, causing temporary permeability of the cell membrane, through which a foreign material such as DNA may pass.

electroporation

a method in which CELLS are subjected to an electrical impulse that leads to the temporary formation of pores in the cell MEMBRANE. Such pores enable commodities such as DNA, PROTEINS and ATP to pass into the cell, before the pores are repaired. Electroporation provides a means of transforming cells (see TRANSFORMATION). It can also be used to deliver DRUGS across the skin and to transfer GENETIC MATERIAL to targetted cells, in GENE THERAPY.
References in periodicals archive ?
Mir, "Evaluation of cell membrane electropermeabilization by means of a nonpermeant cytotoxic agent," BioTechniques, vol.
Puc et al., "Mechanisms of in vivo DNA electrotransfer: respective contribution of cell electropermeabilization and DNA electrophoresis," Molecular Therapy, vol.
Mir, "Enhancement of cytotoxicity by electropermeabilization: an improved method for screening drugs," Anti-Cancer Drugs, vol.
Rols, "Electropermeabilization, a physical method for the delivery of therapeutic molecules into cells", Biochimica et Biophysica Acta (BBA)--Biomembranes, vol.
Novickij, "Irreversible electropermeabilization of the human pathogen Candida albicans: an in vitro experimental study", European Biophysics Journal, pp.