eflornithine


Also found in: Wikipedia.

eflornithine

 [ef-lor´nĭ-thēn″]
an inhibitor of the enzyme catalyzing the decarboxylation of ornithine; used topically as the hydrochloride salt to reduce unwanted facial hair in females. It has also been administered intravenously in treatment of African trypanosomiasis.

eflornithine

An antiprotozoal drug used to treat Pneumocystis carinii pneumonia and African TRYPANOSOMIASIS. The drug is on the WHO official list.
References in periodicals archive ?
DFMO (eflornithine HCl) has been commissioned by the World Health Organization for decades in the treatment of patients with African sleeping sickness and has a robust safety profile for use in children.
Many different treatment modalities are available for the management of hirsutism in PCOS including non-pharmacological and pharmacological therapies like eflornithine OCPs, metformin, cyproterone acetate, and spironolactone.
"We do cover eflornithine, but there is a problem ..."
The World Health Organization (WHO) and China CDC helped obtain nifurtimox and eflornithine, which we administered to the patient within 48 h after the diagnosis.
The HAT disease can be treated by using drugs such as suramin, eflornithine, melarsoprol, and pentamidine.
Madka et al., "Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling," Cancer Prevention Research, vol.
Eflornithine cream is an FDA category C drug for use in pregnancy.
A quarter of the female patients in the study were treated with eflornithine hydrochloride, which inhibits hair cell growth, while fewer than 2% of males received this treatment.
Eflornithine hydrochloride (Vaniqa) may also help slow the hair growth on the face.
This combination consisted of sulindac, which is an older, established antiinflammatory medication, and [alpha]-difluoromethylornithine (DFMO), or eflornithine, a failed cancer-therapeutic drug that was later found to be a highly effective depilatory.