calcium disodium forms stable chelates with a number of metals, but it is primarily used for lead overdose, either alone or in combination with dimercaprol.
calcium disodium (lead) is used either alone or in combination with dimercaprol.
(8,17) Based on the package insert information, the brand name product was reformulated in 2005 from containing no excipients or preservatives to containing edetate
disodium dehydrate and sodium citrate.
(Reidel Dehan AG sleeze Hannover) sodium chloride NaCl (Merck) sodium hydroxide (Fluka AG) chloroform (Merck) DTNB of Sigma company cadmium acetate (Sigma) Reduced form of GSH of Fluka HCl 35% (Kolchlight) distilled water double refined potassium dihydrogen phosphate (Merck) water for injection (Elexor laboratories).
Initial emergency stabilization treatment included the administration of diazepam (0.5 mg/kg IM); calcium glubionate (100 mg/kg PO); calcium gluconate (100 mg/kg IM); supplemental fluids (45 mL/kg SC; Normosol-R, Hospira, Inc, Lake Forest, IL, USA); doxycycline (60 mg/kg IM; Vibravenos formulation, Pfizer Laboratories, London, Ontario, Canada); vitamins A, D, and E (3300 IU/kg IM; Northwest Pharmacy and Compounding Center, Houston, TX, USA); and edetate
calcium disodium (35 mg/kg IM; calcium disodium versenate, 3M Pharmaceuticals, Northridge, CA, USA).
In this current clinical study, the doctors compared different chelation protocols and two forms of EDTA (sodium calcium edetate
and sodium edetate
) in treatments of toxic metal exposure.
In the rare instances that "edetate
", or ethylene diamine tetracetic acid (EDTA) is used, particular care should be made to ensure that only disodium calcium EDTA salt is used (trade name Versinate in the United States), and not disodium EDTA (trade name Endrate in the United States).
It has been shown that recovery of serum calcium concentrations following an acute lowering with edetate
calcium disodium (EDTA) is unaffected in patients taking pamidronate (a bisphosphonate similar to alendronate) chronically for osteoporosis (13).
Blood lead levels and body lead burden assessed by 72-hour urinary lead excretion after the intravenous infusion of 1 g of calcium disodium EDTA (edetate
calcium disodium [Calcium Disodium Versenate], Abbott Laboratories) were measured by electrothermal atomic-absorption spectrometry (model 5100 PC, Perkin-Elmer) with Zeeman background correction and L'vov platform.
Mobilization of lead by calcium disodium edetate
: a reappraisal.
[5.] Davis FA, Becker FO, Michael JA, Sorensen E: Effect of intravenous sodium bicarbonate, disodium edetate
(Na2EDTA), and hyperventilation on visual and oculomotor signs in multiple sclerosis.
Despite chelation therapy with British antilewisite and calcium disodium edetate
(CaNa[sub.2]-EDTA), the child developed seizures, became comatose, and died 26 hours after admission.